{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:40:14Z","timestamp":1778586014427,"version":"3.51.4"},"reference-count":30,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Complement Med Res"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> In \u03b2-thalassemia major (\u03b2-TM) patients, iron overload is one of the main causes of inflammation. This study investigated whether use of silymarin could improve inflammatory status in patients with \u03b2-TM and iron overload, through a placebo-controlled, crossover study. <b><i>Methods:<\/i><\/b> Silymarin (140 mg, 3 times a day) or placebo were prescribed to all patients (<i>n<\/i> = 82) for 12 weeks, and after a 2-week washout period, patients were crossed over to the other group. The efficacy of silymarin was assessed by measuring serum C-reactive protein (CRP) (mg\/dL), interleukin (IL)-6 (pg\/mL), and IL-10 (pg\/mL). <b><i>Results:<\/i><\/b> Sixty-nine patients completed the study. Data analysis showed that compared to the placebo, silymarin could decrease CRP, IL-6, and raise IL-10 signi\ufb01cantly (the <i>p<\/i> values for all variables were &#x3c;0.001). Cohen\u2019s <i>d<\/i> for CRP adjusted according to the baseline CRP value was \u20131.72, the 95% confidence interval (CI) \u20132.12 to \u20131.33. The adjusted Cohen\u2019s <i>d<\/i> equal to \u20131.12, 95% CI \u20131.48 to \u20130.76, and 0.78, 95% CI 0.43\u20131.12, were also estimated for IL-6 and IL-10, respectively. <b><i>Conclusion:<\/i><\/b> The results of the current study demonstrate that the combination of iron chelation therapy with silymarin can improve inflammatory status in patients with \u03b2-TM in the clinical setting. <\/jats:p>","DOI":"10.1159\/000509829","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T21:00:31Z","timestamp":1600981231000},"page":"123-130","source":"Crossref","is-referenced-by-count":10,"title":["Can Use of Silymarin Improve Inflammatory Status in Patients with \u03b2-Thalassemia Major? 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