{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:41:11Z","timestamp":1773279671262,"version":"3.50.1"},"reference-count":17,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The present study aims to describe the efficacy and safety of onabotulinum toxin A (BonT-A) with evaluation of treatment satisfaction and impact on quality of life in chronic migraine (CM) patients in real life. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This study was conducted in CM patients who were treated with BoNT-A with 12 months of follow-up. Data about outcome, adverse events, and patients\u2019 pre- and post-treatment status including health-related quality of life data were analyzed. Health-related quality of life scores were measured at baseline and months 6 and 12 after the beginning of BoNT-A administration. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Of 42 enrolled patients, 30 were included in the analysis. At 12 months, all patients showed a reduction in number of headaches and analgesic use per month and none reported adverse events. After BoNT-A supplementation, health-related quality-of-life scores improved significantly. There was a direct association between health-related quality of life with reduction of headache days at the end of study. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; This study confirms that BoNT-A treatment is effective on CM and improves the functional well-being and quality of life of patients. <\/jats:p>","DOI":"10.1159\/000509853","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T21:00:36Z","timestamp":1600894836000},"page":"517-522","source":"Crossref","is-referenced-by-count":5,"title":["Effectiveness, Safety, and Health-Related Quality of Life of Chronic Migraine Patients Treated with Onabotulinum Toxin A"],"prefix":"10.1159","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5158-8834","authenticated-orcid":false,"given":"Yesim","family":"Beckmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"\u00c7etin \u00dcnc\u00fc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00fclay","family":"Kurt \u0130ncesu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabiha","family":"T\u00fcre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13630"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000323925.29520.e7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01678.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-015-2140-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0953-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2009.00305.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2020.02.017"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2012.02223.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01932.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0373-15.2015"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.03.001"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2015"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-1038-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-0906-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01566.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/head.13653"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-019-00824-3"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509853","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/509853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:50:53Z","timestamp":1745423453000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000509853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":17,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,11,18]]},"published-print":{"date-parts":[[2020,11,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000509853","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}