{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:22:40Z","timestamp":1792174960431,"version":"4.4.0"},"reference-count":31,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>Introduction: Dysphagia is a common symptom that occurs in patients with diabetes mellitus (DM). There have been few prospective observational studies on esophageal motility disorders in DM using high-resolution manometry (HRM). This study aimed to clarify the characteristics of esophageal motility disorders using HRM in patients with dysphagia and compare them between DM and non-DM patients. Methods: Patients with dysphagia were prospectively recruited between October 2018 and July 2019. Patients (n = 89) underwent esophagogastroduodenoscopy and HRM and completed the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire. Manometry parameters and motility disorder classifications were compared between DM and non-DM patients. We also investigated the differences in clinical backgrounds and questionnaire scores among DM patients with normal and abnormal manometry results. Results: A higher prevalence of esophageal motility disorder was observed in DM patients (60%, 21\/35) compared to non-DM patients (29.6%, 16\/54) (p = 0.001). The prevalence of minor disorders such as ineffective esophageal motor disorder and fragmented peristalsis was significantly higher (45 vs. 11%), and the distal contractile integral, integrated relaxation pressure, and contractile front velocity values were lower in the DM group. Among DM patients, those with abnormal esophageal motility had a significantly higher prevalence of neuropathy, retinopathy, and nephropathy, as well as higher reflux or constipation scores on the GSRS, than those with normal results. Conclusions: Among patients with dysphagia, the frequency of minor esophageal motility disorders was higher in DM patients than in non-DM patients. Abnormal esophageal motility related to poor esophageal clearance was associated with higher prevalence of diabetic complications. <\/jats:p>","DOI":"10.1159\/000510081","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T21:01:33Z","timestamp":1599685293000},"page":"554-562","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of High-Resolution Manometry in Patients Complaining of Dysphagia among Patients with or without Diabetes Mellitus"],"prefix":"10.1159","volume":"102","author":[{"given":"Koichi","family":"Muroi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoji","family":"Miyahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3869-1420","authenticated-orcid":false,"given":"Kohei","family":"Funasaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunaki","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4994-016X","authenticated-orcid":false,"given":"Takeshi","family":"Yamamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5814-3555","authenticated-orcid":false,"given":"Takuya","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eizaburo","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5444-143X","authenticated-orcid":false,"given":"Masanao","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3720-781X","authenticated-orcid":false,"given":"Hiroki","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Onoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Arima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Hirooka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Fujishiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s11938-017-0153-z"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-98-3-378"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(69)80060-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199909000-00014"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.26264"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2169-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.709"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0025-7125(16)32496-8"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.3.503"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12477"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/294032"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2.172"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1098086"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.11405\/nisshoshi.112.982"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.56.7775"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12446"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/bf00581037"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.428"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000894"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.12.016"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12476"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90005-j"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03862.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s005350170107"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310000645"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.2.371"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1159\/000201011"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.14.11.1086"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.04.009"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.289"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1097\/mcg.0000000000001206"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/dig\/article-pdf\/102\/4\/554\/4028849\/000510081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/dig\/article-pdf\/102\/4\/554\/4028849\/000510081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:53:11Z","timestamp":1745423591000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000510081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,9]]},"references-count":31,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,6,29]]},"published-print":{"date-parts":[[2021,7,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000510081","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,9]]}}}