{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:00:09Z","timestamp":1777946409842,"version":"3.51.4"},"reference-count":8,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Ophthalmol"],"abstract":"<jats:p>Corneal neovascularization (CNV) has a variety of causes and threatens corneal clarity, thus optimal visual acuity. Conventional medical management includes topical steroids and matrix metalloproteinase inhibitors like doxycycline. Anti-vascular endothelial growth factor (anti-VEGF) agents have demonstrated promise but remain off-label for this indication. However, these agents hold value in cases refractory to first-line medical management. We report the case of a 63-year-old woman who presented with ocular rosacea and CNV affecting vision, on a background of acne rosacea. She was initially treated with fluorometholone and doxycycline, yet continued to deteriorate. Eventually she received two 1.5-mg subconjunctival injections of bevacizumab 2 months apart. CNV completely resolved and results were maintained at 4-year follow-up. This case demonstrates that refractory CNV can be effectively treated with subconjunctival injection of anti-VEGF bevacizumab. The resolution of CNV was also maintained years after injection with minimal adjunctive therapy during this period, and to our knowledge there are no other studies reporting a follow-up period of 4 years after treatment. This is a pertinent case for other clinicians treating patients in a similar situation. <\/jats:p>","DOI":"10.1159\/000510114","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T22:27:04Z","timestamp":1607380024000},"page":"652-657","source":"Crossref","is-referenced-by-count":5,"title":["Resolution of Refractory Corneal Neovascularization with Subconjunctival Bevacizumab"],"prefix":"10.1159","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8790-2466","authenticated-orcid":false,"given":"Anna\u00a0Krystyna","family":"Britton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basil\u00a0Bamford","family":"Crayford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,12,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-302137"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.22336\/rjo.2019.4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3182542613"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/178132"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2010.24.4.230"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31823f8d71"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.07.012"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4571"}],"container-title":["Case Reports in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:53:32Z","timestamp":1745423612000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000510114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,7]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,1,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000510114","archive":["Portico"],"relation":{},"ISSN":["1663-2699"],"issn-type":[{"value":"1663-2699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,7]]}}}