{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:02:41Z","timestamp":1781712161187,"version":"3.54.5"},"reference-count":8,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Gastroenterol"],"abstract":"<jats:p>Hepatocellular adenomas (HCA) are rare benign tumors of the liver, occurring predominantly in females using oral contraceptives. Our case describes a 66-year-old woman presenting with a palpable mass in her upper abdomen. Contrast-enhanced computed tomography and magnetic resonance imaging showed a large exophytic mass protruding from the caudal border of liver segments IV and V, without visible metastases. Laparoscopic resection of the tumor and gallbladder was performed. Histopathological examination showed a hepatocellular carcinoma with areas of HNF1a-HCA (H-HCA). This case shows that malignant transformation is possible in H-HCA. We present our preoperative decision-making process, as well as the role of imaging techniques in this rare case. <\/jats:p>","DOI":"10.1159\/000510215","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T22:00:55Z","timestamp":1604354455000},"page":"577-585","source":"Crossref","is-referenced-by-count":2,"title":["Malignant Transformation of an HNF1a-Inactivated Hepatocellular Adenoma to Hepatocellular Carcinoma"],"prefix":"10.1159","volume":"14","author":[{"given":"Joris\u00a0T.","family":"Hepkema","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9231-8686","authenticated-orcid":false,"given":"Floris\u00a0B.","family":"Poelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette\u00a0S.H.","family":"Gouw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robbert\u00a0J.","family":"de\u00a0Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien\u00a0W.","family":"Duiker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Blokzijl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost\u00a0M.","family":"Klaase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,11,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2017.01.003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14074"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(96)80305-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.07.061"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.04.001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0374-x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i32.7236"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.08.004"}],"container-title":["Case Reports in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510215","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:54:15Z","timestamp":1745423655000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000510215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,2]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,1,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000510215","archive":["Portico"],"relation":{},"ISSN":["1662-0631"],"issn-type":[{"value":"1662-0631","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,2]]}}}