{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T22:39:13Z","timestamp":1777156753610,"version":"3.51.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Seafood is an important source of nutrition in Asia. However, it was believed to cause or aggravate atopic dermatitis (AD). &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; We aim to determine relevant seafood sensitization among adults with AD and investigate cross-sensitization to aeroallergens. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; One hundred thirty-two adults with AD who were subjected to skin prick test (SPT) with 7 common local seafood allergens (anchovy, tuna, mackerel, squid, giant freshwater prawn, shrimp, and crab), house dust mites (HDMs), and cockroach were analyzed retrospectively. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The median age of the study subjects was 32 years (range 17\u201377 years) with a male to female ratio of 1:3. The mean duration of AD was 16 years. Eighty-two patients (62.2%) had other atopic conditions. Using SCORAD, 44.7% had mild, 42.4% moderate, and 12.9% severe disease. Eighty-six patients (65.2%) self-reported to have seafood allergy, with the main symptoms of transient pruritus and erythema within 2 h of ingestion. SPT revealed 51.5% of the patients were sensitized to at least 1 of the 7 seafood allergens. The relevant sensitization rate was 45.1%. Interestingly, 46% of those without a history of seafood allergy developed at least 1 positive reaction in the SPT. Prawn, shrimp, and crab were the 3 most frequently sensitized allergens. Nearly all patients (98.3%) who were sensitized to crustaceans were also sensitized to HDMs and\/or cockroach. There was no significant correlation between a positive SPT to seafood with age, age of onset of AD, duration, and severity of AD, and the presence of other atopic diatheses. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The relevant sensitization rate of local seafood among adults with AD was 45.1%. <\/jats:p>","DOI":"10.1159\/000510314","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T21:00:33Z","timestamp":1600117233000},"page":"153-157","source":"Crossref","is-referenced-by-count":8,"title":["Sensitization to Local Seafood Allergens in Adult Patients with Atopic Dermatitis in Malaysia"],"prefix":"10.1159","volume":"182","author":[{"given":"Hock Leng","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7760-3238","authenticated-orcid":false,"given":"Min Moon","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Faizal","family":"Bakhtiar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zailatul Hani","family":"Mohamad Yadzir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmah","family":"Johar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1989.tb01404.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7762\/cnr.2013.2.1.52"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05888.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2005.02002.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.12809\/hkmj164684"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14004"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S2221-1691(11)60189-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12648"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1826-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2018.04.008"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2016.8.2.101"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-020-0902-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(00)70211-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph120910984"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e318194c0de"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00328.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2008.00477.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.01034.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-012-0354-4"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21062234"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:55:00Z","timestamp":1745423700000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000510314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,14]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,1,28]]},"published-print":{"date-parts":[[2021,1,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000510314","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.12950810","asserted-by":"subject"}]},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,14]]}}}