{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T07:12:21Z","timestamp":1779001941099,"version":"3.51.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Objective:<\/i><\/b> The aim of the study was to report on the presentation and outcomes of vesicular cystitis (VC), a chronic cystitis exhibiting translucent bladder mucosal vesicles, among women with antibiotic-refractory recurrent urinary tract infections (RUTIs). <b><i>Methods:<\/i><\/b> An analysis of our Institutional Review Board-approved series on antibiotic-refractory RUTIs was performed, selecting for documented VC lesions on cystoscopy. All patients had RUTIs defined as \u22653 urinary tract infections\/year with positive urine culture. All patients were extensively treated with antibiotics with no resolution of RUTIs and were offered electrofulguration (EF) of VC lesions under anesthesia as a last resort. All patients had a 6-month post-EF office cystoscopy documenting persistence or resolution of the lesions, and a clinical outcome assessment based on RUTI frequency. <b><i>Results:<\/i><\/b> Of 482 patients, 18 (3.7%) treated during 2011\u20132017 met the study criteria. VC was most commonly found over the dome\/anterior wall (7\/18, 38%) and as pancystitis (7\/18, 38%). There was often concomitant cystitis cystica of the trigone (8\/18, 44%). At post-EF cystoscopy, persistence of VC was noted in 10\/18 (56%) patients; 6\/18 (33%) underwent repeat EF and an additional 3\/18 (17%) were retreated due to new lesions after initial resolution. Two (11%) patients required simple cystectomy and urinary diversion due to RUTIs refractory to all interventions. Within a median follow-up of 2.8 years after EF, clinical cure was observed in 5\/18 (28%), improvement in 10\/18 (56%), and failure in 3\/18 (17%) patients. <b><i>Conclusions:<\/i><\/b> Among women with antibiotic-refractory RUTIs, VC is an infrequent and persistent form of cystitis with a predilection for non-trigonal bladder surfaces, whose management is challenging. <\/jats:p>","DOI":"10.1159\/000510320","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T21:00:32Z","timestamp":1602882032000},"page":"131-136","source":"Crossref","is-referenced-by-count":9,"title":["Vesicular Cystitis: A Chronic Cystitis Variant Often Unresponsive to Antibiotics and Electrofulguration"],"prefix":"10.1159","volume":"105","author":[{"given":"Joseph J.","family":"Crivelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe E.","family":"Zimmern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602136103"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.04.008"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.urols.2015.08.005"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13963"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1988.tb07109.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(17)69738-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(17)55849-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(17)34899-1"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000485257"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510320","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:55:03Z","timestamp":1745423703000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000510320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,16]]},"references-count":9,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2021,1,20]]},"published-print":{"date-parts":[[2021,2,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000510320","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.13102085","asserted-by":"subject"}]},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,16]]}}}