{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:13:26Z","timestamp":1791976406210,"version":"4.4.0"},"reference-count":23,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Introduction:<\/i><\/b> The European Network of Drug Allergy and the European Academy of Allergy and Clinical Immunology have classified hypersensitivity reactions induced by nonsteroidal anti-inflammatory drugs (NSAIDs) into 5 phenotypes according to the pathophysiology, clinical manifestations, number of drugs involved, and the presence of underlying diseases. This classification does not include anaphylaxis as part of NSAID cross-reactivity. The objective of this study was to characterize a group of patients with anaphylactic NSAID cross-reactivity. <b><i>Method:<\/i><\/b> This was a retrospective, descriptive, observational study. Patients who developed anaphylaxis to one NSAID plus another acute reaction (anaphylactic or not) to at least one other NSAID of a different chemical group were included. Demographic and clinical characteristics and the diagnostic approach were studied. <b><i>Results:<\/i><\/b> A total of 38 patients were included, 28 (73.7%) of whom were women. The mean age was 40 \u00b1 17.7 years. The main organs affected in the anaphylactic reaction were the skin and the respiratory system, occurring in 35 (92.1%) and 33 (86.8%) patients, respectively. Thirty-two (84.3%) patients presented with cutaneous and respiratory involvement simultaneously. The main anti-inflammatory agent involved in anaphylactic reactions was acetylsalicylic acid in 9 (23.7%) patients, followed by dipyrone in 8 (21.1%). The most frequent allergic comorbidity was rhinitis in 20 (52%) patients. Skin tests were performed in 15 (39.5%) patients, showing positivity in 12 (80%), mainly to mites. A total of 36 of 38 patients were challenged with alternative drugs, and 35 (97.2%) tolerated meloxicam and\/or etoricoxib. <b><i>Conclusion:<\/i><\/b> In the present study, NSAID cross-anaphylaxis was more frequent in women, and acetylsalicylic acid and dipyrone were the main triggers. Rhinitis was the main allergic comorbidity, and there was a high incidence of atopy. The majority tolerated selective COX-2 NSAIDs. <\/jats:p>","DOI":"10.1159\/000510335","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T21:00:30Z","timestamp":1600722030000},"page":"131-138","source":"Crossref","is-referenced-by-count":5,"title":["Descriptive Analysis of Cross-Reactive Anaphylaxis as a Different Clinical Subtype of Nonsteroidal Anti-Inflammatory Drug (NSAID) Hypersensitivity"],"prefix":"10.1159","volume":"182","author":[{"given":"Laura del Mar","family":"V\u00e1squez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Lucia","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Fernando","family":"Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Olaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Daniel","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2014.04.001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2017.1377072"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-12-200406150-00009"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2016.085"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-015-0080-1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2015.07.019"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.06.012"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00614"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s0091-6749(96)70102-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/all.12260"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2014.03.014"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03774.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03651.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34668-1"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12140"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000454"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000077"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0080"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.3590"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02554.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00279.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-016-0122-3"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2011.02601.x"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510335","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:55:11Z","timestamp":1745423711000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000510335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,21]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,1,28]]},"published-print":{"date-parts":[[2021,1,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000510335","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,21]]}}}