{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:20:33Z","timestamp":1783383633186,"version":"3.54.6"},"reference-count":15,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Introduction:<\/i><\/b> Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) is reported to be the most common drug hypersensitivity. The aim of this study was to evaluate the characteristics of self-reported NSAID hypersensitivity and identify patients at high risk of NSAID hypersensitivity. <b><i>Methods:<\/i><\/b> Patients who presented at a single tertiary care hospital between January\u2013December 2017 with reported NSAID hypersensitivity were evaluated. Clinical information obtained from a review of medical records was further supplemented with data gained from a telephone-administered questionnaire. <b><i>Results:<\/i><\/b> From a total of 535 patients with reported NSAID hypersensitivity, 301 were included in the study. The mean age of onset of NSAID hypersensitivity reaction was 30.3 \u00b1 14.9 years old. A total of 84 patients (27.9%) were hypersensitive to 2 or more chemically unrelated NSAIDs. The leading NSAID hypersensitivity was to propionic acid derivatives (73%) followed by acetic acid derivatives (28.9%). Immediate reaction (\u22641 h) was identified in 171 patients (57.8%), and angioedema was the most frequently reported symptom (179 patients, 59.5%), followed by urticaria and anaphylaxis in 85 (28.2%) and 62 (20.6%) patients, respectively. A drug provocation test was performed on 53 patients, and NSAID hypersensitivity was confirmed in 38 patients (71.6%). The independent factors identified, which could predict NSAID hypersensitivity, were personal history of allergic rhinitis\/chronic rhinosinusitis (AR\/CRS), onset of NSAID hypersensitivity over 15 years old, and immediate reaction. <b><i>Conclusion:<\/i><\/b> Angioedema was the most typical symptom, and propionic acid derivatives were the most frequently reported culprit drugs. The significant risk factors predicting NSAID hypersensitivity were personal history of AR\/CRS, onset of NSAID hypersensitivity reaction over 15 years old, and immediate reaction. <\/jats:p>","DOI":"10.1159\/000510364","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T21:00:27Z","timestamp":1600462827000},"page":"139-145","source":"Crossref","is-referenced-by-count":9,"title":["Characteristics and Contributing Factors Related to Nonsteroidal Anti-Inflammatory Drugs Hypersensitivity"],"prefix":"10.1159","volume":"182","author":[{"given":"Araya","family":"Yuenyongviwat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisarat","family":"Chantaravisarut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassamon","family":"Phattarapongdilok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanlaya","family":"Koosakulchai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wipa","family":"Jessadapakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasuree","family":"Sangsupawanich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,9,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02870.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2016.04.016"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/all.12260"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/all.12266"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12039"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-015-0052-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2016.37.3917"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2016.10.004"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/all.12774"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/all.12689"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03648.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000337660"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000452627"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2011.02601.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12013"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510364","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:55:26Z","timestamp":1745423726000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000510364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,18]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,1,28]]},"published-print":{"date-parts":[[2021,1,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000510364","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,18]]}}}