{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:00:35Z","timestamp":1760551235936,"version":"3.40.5"},"reference-count":23,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; There are a limited number of studies investigating the relationship between the degree of liver fibrosis and the long-term prognosis, especially ischemic stroke (IS) recurrence, in first-ever IS or transient ischemic attack (TIA). &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; We investigated whether there are differences in the long-term all-cause and cardiovascular mortalities and IS recurrence based on the degree of liver fibrosis in first-ever IS or TIA. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This analysis included 2,504 patients with first-ever IS or TIA recruited from a prospective stroke cohort. Liver fibrosis was predicted using the fibrosis-4 (FIB-4) index, and advanced fibrosis was defined as an FIB-4 index of &amp;#x3e;3.25. Using Cox regression models, we compared the all-cause and cardiovascular mortalities and IS recurrence. As measures for the additive predictive value of the FIB-4 index for prediction of all-cause mortality, the integrated area under the receiver operating characteristic curve (iAUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were used. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; There were 231 (9.2%) patients with advanced fibrosis. During a median follow-up of 1.2 years, the cumulative all-cause and cardiovascular mortalities were 6.4 and 1.9%, and IS recurrence was observed in 5.3%. The advanced fibrosis was associated with an increased risk of all-cause mortality (hazard ratio [HR] = 3.98, 95% confidence interval [CI] = 2.40\u20136.59), cardiovascular mortality (HR = 4.48, 95% CI = 1.59\u201312.65), and IS recurrence (HR = 1.95, 95% CI = 1.05\u20133.65). Adding the FIB-4 index to the model consisting of traditional cardiovascular risk factors improved the predictive accuracy for all-cause mortality as measured using the iAUC (from 0.7594 to 0.7729) and for all-cause mortality at 1 year as measured using the NRI (38.6%) and IDI (0.037). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The burden of liver fibrosis is associated with unfavorable long-term prognosis, including recurrent IS, in first-ever IS or TIA. <\/jats:p>","DOI":"10.1159\/000510436","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T21:00:31Z","timestamp":1601067631000},"page":"474-480","source":"Crossref","is-referenced-by-count":27,"title":["Advanced Liver Fibrosis Predicts Unfavorable Long-Term Prognosis in First-Ever Ischemic Stroke or Transient Ischemic Attack"],"prefix":"10.1159","volume":"49","author":[{"given":"Minyoul","family":"Baik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo Suk","family":"Nam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hoe","family":"Heo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Jong","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beom Kyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Yong","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do 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Dae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24282"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520903171284"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.043"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27368"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.013"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i7.1724"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.04.005"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.02.005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000497069"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21178"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2009.08.002"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2019.0001n"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29285"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2005.030814.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2929"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v5.i11.621"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26156"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2017-000598"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2018.1558760"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.119.028161"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1161\/circimaging.117.007241"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185402"}],"container-title":["Cerebrovascular 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