{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:19:46Z","timestamp":1781756386657,"version":"3.54.5"},"reference-count":36,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> Numerous studies have shown the association between eosinophilia and clinical outcomes of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). But the evidences are lack of consensus. <b><i>Objective:<\/i><\/b> The aim of this meta-analysis was to conduct a pooled analysis of outcome comparing eosinophilic (EOS) AECOPD and non-EOS AECOPD patients. <b><i>Methods:<\/i><\/b> We included PubMed, EMBASE, Web of Science, and Cochrane databases up to 2020 to retrieve articles. Randomized controlled trials and quasi-experimental studies about patients with and without EOS AECOPD in terms of in-hospital mortality, length of hospital stay, comorbidities, forced expiratory volume in 1 s (FEV1), gender, and BMI were included preclinical studies, review articles, editorials, commentaries, conference abstracts, and book chapters were excluded. The methodologic assessment of studies was performed with the Newcastle-Ottawa Scale and Cochran scale. Comprehensive Rev Man 5 was used for the statistical analysis. <b><i>Results:<\/i><\/b> Twenty-one studies with 18,041 patients fulfilled the inclusion criteria and were used in this meta-analysis. Comparing to the non-EOS group, those with EOS AECOPD patients had a lower risk for in-hospital mortality (odds ratio (OR) = 0.59, 95% confidence interval [CI] 0.36\u20130.95, <i>p<\/i> = 0.03), shorter length of hospital stay (OR = \u22120.72, 95% CI \u22121.44 to \u22120.00, <i>p<\/i> = 0.05), better FEV1 (mean difference = 0.14, 95% CI 0.08\u20130.20, <i>p<\/i> &#x3c; 0.00001), and a lower risk of arrhythmias (OR = 1.50, 95% CI 1.01\u20132.21, <i>p<\/i> = 0.04). In addition, the non-EOS group had a higher percentage of male (OR = 1.34, 95% CI 1.15\u20131.56, <i>p<\/i> = 0.0002) than EOS group. The rate of steroid use (OR = 0.82, 95% CI 0.47\u20131.42, <i>p<\/i> = 0.48) and BMI (mean difference = 0.43, 95% CI \u22120.18 to 1.05, <i>p<\/i> = 0.17] had no difference between 2 groups. <b><i>Conclusion:<\/i><\/b> The results of our meta-analysis suggest that EOS AECOPD patients have a better clinical outcome than non-EOS AECOPD patients in terms of length of hospital stay, in-hospital mortality, FEV1, and risk of arrhythmias. In addition, the non-EOS AECOPD patients have higher percentage of male than EOS AECOPD patients. <\/jats:p>","DOI":"10.1159\/000510516","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T22:00:39Z","timestamp":1609279239000},"page":"228-237","source":"Crossref","is-referenced-by-count":12,"title":["Blood Eosinophils and Clinical Outcome of Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis"],"prefix":"10.1159","volume":"100","author":[{"given":"Yajie","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo chao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,12,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12780"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.5.8630628"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200506-859OC"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00162414"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00004002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.5.9804028"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02872-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2011.02565.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00050-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201104-0597OC"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S100338"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201108-1553OC"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00047504"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13423"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/ S2213-2600(15)00106-X"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S190085"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2017.07.064"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30176-6"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2016.03.004"},{"key":"ref20"},{"key":"ref21"},{"key":"ref22"},{"key":"ref23"},{"key":"ref24"},{"key":"ref25"},{"key":"ref26"},{"key":"ref27"},{"key":"ref28"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70187-0"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00078002"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00180812"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057678"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1996.tb00606.x"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.1.2007050"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S90330"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.01.026"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510516","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:57:06Z","timestamp":1745423826000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000510516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,29]]},"references-count":36,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3,11]]},"published-print":{"date-parts":[[2021,3,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000510516","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,29]]}}}