{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:50:33Z","timestamp":1788187833277,"version":"build-2803163510"},"reference-count":12,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Appendage Disord"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Alopecia areata (AA) is a form of nonscarring alopecia and one of the most common autoimmune disorders. Persistent or severe variants lead to potential disfigurement and are associated with a significant negative impact on the patient\u2019s quality of life. &lt;b&gt;&lt;i&gt;Case Presentation:&lt;\/i&gt;&lt;\/b&gt; A 51-year-old female patient presenting with refractory alopecia universalis was successfully treated with oral tofacitinib. Recurrence was not observed following 17 months of therapy. &lt;b&gt;&lt;i&gt;Discussion\/Conclusion:&lt;\/i&gt;&lt;\/b&gt; None of the currently employed therapies for AA are reliably effective nor are they approved for the disease. In this setting, Janus kinase inhibitors emerge as a promising novel treatment, as increasing evidence supports their effectiveness in AA. <\/jats:p>","DOI":"10.1159\/000510673","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T21:00:33Z","timestamp":1601499633000},"page":"36-40","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness of Oral Tofacitinib Dose Tapering in a Case of Alopecia Areata Universalis"],"prefix":"10.1159","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7940-5451","authenticated-orcid":false,"given":"Mariana","family":"Esteves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Pedrosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.09.007"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2018.04.006"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.89776"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15489"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.0001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.260"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.06.027"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15937"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.01.032"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2019.3668"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14986"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15383"}],"container-title":["Skin Appendage Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510673","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:58:39Z","timestamp":1745423919000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000510673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,19]]},"published-print":{"date-parts":[[2021,2,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000510673","archive":["Portico"],"relation":{},"ISSN":["2296-9195","2296-9160"],"issn-type":[{"value":"2296-9195","type":"print"},{"value":"2296-9160","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,30]]}}}