{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:26:42Z","timestamp":1790414802120,"version":"4.1.0"},"reference-count":23,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> Electromagnetic navigation bronchoscopy (ENB) is a minimally invasive technology for the diagnosis of peripheral pulmonary nodules. However, ENB is limited by the lack of real-time confirmation of various biopsy devices. Cone-beam computed tomography (CBCT) could increase diagnostic yield by allowing real-time confirmation to overcome the inherent divergence of nodule location. <b><i>Objectives:<\/i><\/b> The aim of this study was to assess the diagnostic yield of ENB plus CBCT as compared with ENB alone for biopsy of peripheral lung nodules. <b><i>Method:<\/i><\/b> We conducted a retrospective study of patients undergoing ENB before and after the implementation of CBCT. Data from 62 consecutive patients with lung nodules located in the outer two-thirds of the lung who underwent ENB and combined ENB-CBCT were collected. Radial endobronchial ultrasound was used during all procedures as well. Diagnostic yield was defined as the presence of malignancy or benign histological findings that lead to a specific diagnosis. <b><i>Results:<\/i><\/b> Thirty-one patients had ENB-CBCT, and 31 patients had only ENB for peripheral lung lesions. The median size of the lesion for the ENB-CBCT group was 16 (interquartile range (IQR) 12.6\u201325.5) mm as compared to 21.5 (IQR 16\u201327) mm in the ENB group (<i>p<\/i> = 0.2). In the univariate analysis, the diagnostic yield of ENB-CBCT was 74.2% and ENB 51.6% (<i>p<\/i> = 0.05). Following multivariate regression analysis adjusting for the size of the lesion, distance from the pleura, and presence of bronchus sign, the odds ratio for the diagnostic yield was 3.4 (95% CI 1.03\u201311.26, <i>p<\/i> = 0.04) in the ENB-CBCT group as compared with ENB alone. The median time for the procedure was shorter in patients in the ENB-CBCT group (74 min) than in those in the ENB group (90 min) (<i>p<\/i> = 0.02). The rate of adverse events was similar in both groups (6.5%, <i>p<\/i> = 0.7). <b><i>Conclusions:<\/i><\/b> The use of CBCT might increase the diagnostic yield in ENB-guided peripheral lung nodule biopsies. Future randomized clinical trials are needed to confirm such findings. <\/jats:p>","DOI":"10.1159\/000510763","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T22:04:19Z","timestamp":1609884259000},"page":"44-51","source":"Crossref","is-referenced-by-count":45,"title":["Cone-Beam Computed Tomography-Guided Electromagnetic Navigation for Peripheral Lung Nodules"],"prefix":"10.1159","volume":"100","author":[{"given":"Fayez","family":"Kheir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9749-7479","authenticated-orcid":false,"given":"Sanket R.","family":"Thakore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Uribe Becerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Tahboub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Kamat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramsy","family":"Abdelghani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Fernandez-Bussy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upendra R.","family":"Kaphle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Majid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.180.6.1801665"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.7576"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.08.1366"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.2008.01990.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-3-201108020-00003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2072-1439.2015.12.16"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2457"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2011.02123.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201507-1332OC"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-017-0403-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000500228"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00051-2016"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2353"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0228-y"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/lbr.0000000000000536"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.09.16"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13609"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.11.21"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.02.035"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.7150\/jca.8834"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2481071451"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5350-1"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000490547"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:59:30Z","timestamp":1745423970000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000510763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,2,2]]},"published-print":{"date-parts":[[2021,2,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000510763","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}