{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T02:43:42Z","timestamp":1774665822993,"version":"3.50.1"},"reference-count":34,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> Cr is secreted by the proximal tubules and thus Cr clearance (<i>C<\/i><sub>cr<\/sub>) can overestimate inulin clearance (<i>C<\/i><sub>in<\/sub>). However, in some cases, <i>C<\/i><sub>cr<\/sub> can even underestimate <i>C<\/i><sub>in<\/sub>. This suggests that Cr could be reabsorbed in the tubuli. We examined the clinical parameters that are associated with tubular Cr reabsorption. <b><i>Methods:<\/i><\/b> In 80 kidney donor candidates (53.9 \u00b1 13.2 years, 29 males), <i>C<\/i><sub>in<\/sub> and para-aminohippuric acid clearance were measured simultaneously. Intrarenal hemodynamic parameters were calculated by Gomez\u2019s formulae. To quantify the secretory component of <i>C<\/i><sub>cr<\/sub> (SF<sub>cr<\/sub>), it was calculated as follows: SF<sub>cr<\/sub> = (<i>C<\/i><sub>cr<\/sub> \u2212 <i>C<\/i><sub>in<\/sub>)\/<i>C<\/i><sub>cr<\/sub>. <b><i>Results:<\/i><\/b> Twenty-five subjects (31.3%) showed SF<sub>cr<\/sub> values &#x3c;0. SF<sub>cr<\/sub> that correlated significantly and negatively with efferent arteriolar resistance (<i>R<\/i><sub>e<\/sub>) and glomerular hydrostatic pressure (<i>P<\/i><sub>glo<\/sub>) (<i>R<\/i><sub>e<\/sub>: <i>r<\/i> = \u22120.30, <i>p<\/i> = 0.008; <i>P<\/i><sub>glo<\/sub>: <i>r<\/i> = \u22120.28, <i>p<\/i> = 0.025). In multiple regression analyses, <i>R<\/i><sub>e<\/sub> and <i>P<\/i><sub>glo<\/sub> were significantly and negatively associated with SF<sub>cr<\/sub> after adjustment for other confounders. <b><i>Conclusions:<\/i><\/b> These findings suggest that tubular reabsorption of Cr can occur in some cases. Intrarenal glomerular hemodynamic burden may be related to tubular creatinine reabsorption, which possibly leads to lower <i>C<\/i><sub>cr<\/sub> values. <\/jats:p>","DOI":"10.1159\/000510838","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T22:00:43Z","timestamp":1604613643000},"page":"996-1008","source":"Crossref","is-referenced-by-count":9,"title":["Increased Glomerular Hydrostatic Pressure is Associated with Tubular Creatinine Reabsorption in Healthy 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