{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:32:00Z","timestamp":1747193520776,"version":"3.40.5"},"reference-count":21,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Neurol"],"abstract":"Botulism is an acute paralytic disease caused by botulinum neurotoxin (BoNT)-mediated inhibition of neurosignaling at the neuromuscular junction. BoNTs are produced by gram positive, anaerobic, spore-forming bacteria from the genus <i>Clostridium,<\/i>most commonly<i> Clostridium botulinum<\/i>. Over the last decade, a previously uncommon form of botulism, wound botulism, has increased in prevalence possibly due to the rise in parenteral drug abuse. A 53-year-old patient with a history of drug abuse presents to a rural emergency department with rapidly progressing lower extremity weakness over the past few days. He reports a recent heroin injection into right buttock and diffuse skin-popping scarring was observed throughout. The patient was treated with heptavalent botulinum antitoxin obtained from the Center for Disease Control and Prevention (CDC). A right thigh abscess culture was positive for<i> Clostridium tertium<\/i>, a left hip abscess culture was positive for methicillin-susceptible <i>Staphylococcus aureus<\/i> (MSSA), and blood culture confirmed multi-microbial bacteremia caused by <i>Staphylococcus epidermidis<\/i> and <i>Streptococcus mitis<\/i>. Serum analysis was positive for BoNT type A from a suspected concurrent<i> Clostridium botulinum<\/i> infection as <i>C. tertium<\/i> is not known to produce BoNT type A. This case report highlights the importance of early antitoxin treatment for patients with suspected wound botulism. <\/jats:p>","DOI":"10.1159\/000510846","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T22:01:12Z","timestamp":1605218472000},"page":"422-427","source":"Crossref","is-referenced-by-count":0,"title":["Wound Botulism Caused by Botulinum Neurotoxin Type A in a Chronic Parenteral Drug Abuser"],"prefix":"10.1159","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0054-8319","authenticated-orcid":false,"given":"Sohun","family":"Awsare","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Chirikian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Forshing","family":"Lui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.105567"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3295"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20010"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1124\/pr.116.012658"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-3-199808010-00011"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1086\/444507"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.20.2476"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-017-0300-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-45790-0_11"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a005637"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63432-0.00024-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000083259"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00089-18"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-45790-0_4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05441.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2013.01.005"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3201\/eid0910.030287"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/s0928-4257(01)00086-9"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000069073"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir005"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.11.859"}],"container-title":["Case Reports in Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510846","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:00:24Z","timestamp":1745424024000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000510846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,12]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,1,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000510846","archive":["Portico"],"relation":{},"ISSN":["1662-680X"],"issn-type":[{"type":"electronic","value":"1662-680X"}],"subject":[],"published":{"date-parts":[[2020,11,12]]}}}