{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:32:03Z","timestamp":1747193523510,"version":"3.40.5"},"reference-count":13,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"A standard chemotherapy regimen for advanced thymic carcinoma has not yet been established. We treated 2 cases of thymic carcinoma with carboplatin plus nanoparticle albumin-bound (<i>nab<\/i>)-paclitaxel, and <i>nab<\/i>-paclitaxel maintenance therapy. The first case was a 68-year-old female, admitted for dyspnea and left shoulder pain. Chest computed tomography (CT) showed a huge mass in the anterior mediastinum, pleural and pericardial effusions, and multiple lung metastases. Specimens obtained from the anterior mediastinal mass by CT-guided needle biopsy revealed squamous cell carcinoma of the thymus, which was in stage IVB. The patient was administered carboplatin plus <i>nab<\/i>-paclitaxel as first-line treatment. After 3 cycles of chemotherapy, a partial response was observed with marked shrinkage of the tumor. Following 6 cycles of chemotherapy, <i>nab<\/i>-paclitaxel maintenance therapy was initiated. Disease progression was seen 9.1 months after initiation of treatment. The patient experienced no serious adverse events. The second case was a 70-year-old male who had productive cough, dyspnea, and right-sided chest pain. Chest CT revealed a huge mass in the anterior mediastinum, pericardial effusion, and multiple lymphadenopathies. Specimens obtained from station 11s by endobronchial ultrasound-guided transbronchial needle aspiration revealed undifferentiated thymic carcinoma, which was in stage IVB. Six cycles of carboplatin plus <i>nab<\/i>-paclitaxel were administered, followed by 5 cycles of <i>nab<\/i>-paclitaxel for maintenance. A partial response was seen, which was sustained for more than 13 months. The patient experienced no serious adverse events. These cases show that chemotherapy with carboplatin plus <i>nab<\/i>-paclitaxel and <i>nab<\/i>-paclitaxel as maintenance therapy can be a useful regimen for advanced thymic carcinoma. <\/jats:p>","DOI":"10.1159\/000510894","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T22:03:57Z","timestamp":1608242637000},"page":"1506-1512","source":"Crossref","is-referenced-by-count":5,"title":["Successful Treatment of Advanced Thymic Carcinoma with Carboplatin plus <b><i>nab<\/i><\/b>-Paclitaxel and Maintenance Monotherapy with <b><i>nab<\/i><\/b>-Paclitaxel: Two Case Reports"],"prefix":"10.1159","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9084-1628","authenticated-orcid":false,"given":"Tomoyuki","family":"Araya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6158-7683","authenticated-orcid":false,"given":"Toshiyuki","family":"Kita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamami","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideharu","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Kasahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(03)00555-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezv380"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2009.03.031"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyr089"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.9607"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu541"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12320"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19811201)48:11%3c2485::aid-cncr2820481123%3e3.0.co;2-r"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.5848"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000357938"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3812"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2016.803"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000477758"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510894","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510894","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:01:05Z","timestamp":1745424065000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000510894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,17]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,1,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000510894","archive":["Portico"],"relation":{},"ISSN":["1662-6575"],"issn-type":[{"type":"electronic","value":"1662-6575"}],"subject":[],"published":{"date-parts":[[2020,12,17]]}}}