{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T21:51:58Z","timestamp":1753739518737,"version":"3.40.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Introduction:<\/i><\/b> The effects of lymphocyte subtypes, including helper (Th), natural killer (NK), and regulatory (Treg) cells, and other T-cell subtypes on treatment outcomes in diffuse large B-cell lymphoma (DLBCL) patients are not clearly established. <b><i>Methods:<\/i><\/b> Among 151 consecutive patients diagnosed with DLBCL, we collected peripheral blood samples at diagnosis from 91 patients who received at least 1 cycle of R-CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab) chemotherapy and analyzed lymphocyte subsets by flow cytometry. <b><i>Results:<\/i><\/b> DLBCL patients had a higher proportion of CD4<sup>+<\/sup>CD25<sup>+<\/sup> Treg (<i>p<\/i> &#x3c; 0.001) and lower absolute lymphocyte count than those of healthy controls. Lymphopenia at diagnosis was associated with advanced-stage disease (<i>p<\/i> = 0.001), a high-intermediate\/high-risk International Prognostic Index (IPI) (<i>p<\/i> &#x3c; 0.001), and older age (<i>p<\/i> = 0.060). High-intermediate\/high-risk IPI, high proportion of CD3<sup>+<\/sup>CD4<sup>+<\/sup> Th cells, and extranodal site \u22652 correlated with unfavorable prognostic factors for survival. High proportion of Th cells was associated with fewer cytotoxic T cells and NK cells at the time of diagnosis. <b><i>Conclusion:<\/i><\/b> This study showed an association between circulating lymphocyte subsets including Th cells, Tregs, and NK cells and clinical outcomes in DLBCL; however, further confirmation is needed via prospective trials. <\/jats:p>","DOI":"10.1159\/000510912","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T22:01:32Z","timestamp":1607032892000},"page":"427-437","source":"Crossref","is-referenced-by-count":9,"title":["Prognostic Impact of Peripheral Blood T-Cell Subsets at the Time of Diagnosis on Survival in Patients with Diffuse Large B-Cell Lymphoma"],"prefix":"10.1159","volume":"144","author":[{"given":"Ho-Jin","family":"Shin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JooSeop","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Hwa","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyungi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.1003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.1618"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2006.1.295"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.807"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-359943"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404780"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2008.01129.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-011-0993-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70081-X"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2155"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07028.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp505"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2403"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPUJGMVV6ZF4GG"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2016.04.004"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm110"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/s0065-230x(03)90004-2"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031981"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2010.01.011"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-1999-5"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/nri3447"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1420-3"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-0937-2"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510912","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:01:14Z","timestamp":1745424074000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000510912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,3]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,7,22]]},"published-print":{"date-parts":[[2021,7,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000510912","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.13325867","asserted-by":"subject"}]},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2020,12,3]]}}}