{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:00:38Z","timestamp":1774476038814,"version":"3.50.1"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2021]]},"abstract":"Absolute immature platelet counts (A-IPC) aid in diagnosis and treatment follow-up in thrombotic thrombocytopenic purpura (TTP). A-IPC was used to follow a patient on mycophenolate mofetil (MMF) maintenance therapy treated with a prolonged therapeutic plasma exchange (TPE) regimen for relapsing TTP. On admission, the platelet (PLT) count was 95 \u00d7 10<sup>9<\/sup>\/L declining to 14 \u00d7 10<sup>9<\/sup>\/L in 5 days. Daily TPE was initiated for suspected TTP, and MMF was discontinued. A-IPC and PLT count were 1 \u00d7 10<sup>9<\/sup>\/L and 14 \u00d7 10<sup>9<\/sup>\/L, respectively, prior to first TPE. A-IPC improved to 3.2 \u00d7 10<sup>9<\/sup>\/L with 1 TPE, and on day 5, A-IPC and PLT count were 7.5 \u00d7 10<sup>9<\/sup>\/L and 218 \u00d7 10<sup>9<\/sup>\/L, respectively. On day 6, A-IPC and PLT count decreased to 4.8 \u00d7 10<sup>9<\/sup>\/L and 132 \u00d7 10<sup>9<\/sup>\/L further worsening to 0.4 \u00d7 10<sup>9<\/sup>\/L and 13 \u00d7 10<sup>9<\/sup>\/L, respectively. ADAMTS13 activity remained &#x3c;5% with an inhibitor; counts did not recover. Initial improvement followed by rapidly declining A-IPC despite therapy suggested production suppression. In TTP, A-IPC may aid in establishing early therapy effects over PLT production. <\/jats:p>","DOI":"10.1159\/000510913","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T22:00:32Z","timestamp":1606341632000},"page":"465-469","source":"Crossref","is-referenced-by-count":7,"title":["Absolute Immature Platelet Counts Suggest Platelet Production Suppression during Complicated Relapsing Thrombotic Thrombocytopenic Purpura"],"prefix":"10.1159","volume":"144","author":[{"given":"Sirisha","family":"Kundrapu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hollie M.","family":"Reeves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5424-5519","authenticated-orcid":false,"given":"Robert W.","family":"Maitta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,11,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017005124"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13571"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108083250604"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13658"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-02-791533"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085465"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-321398"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1532\/LH96.06012"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12912"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12929"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2018.04.001"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24484"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2014.07.004"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13974"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2019.05.011"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2013.07.005"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03646.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806311"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13182"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192064"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2007.00832.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1213206"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.84"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199903150-00011"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/510913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:01:15Z","timestamp":1745424075000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000510913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,25]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,7,22]]},"published-print":{"date-parts":[[2021,7,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000510913","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,25]]}}}