{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:09:43Z","timestamp":1790726983687,"version":"4.1.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Visc Med"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Introduction:<\/i><\/b> Lipoedema is characterized as subcutaneous lipohypertrophy in association with soft-tissue pain affecting female patients. Recently, the disease has undergone a paradigm shift departing from historic reiterations of defining lipoedema in terms of classic edema paired with the notion of weight loss-resistant leg volume towards an evidence-based, patient-centered approach. Although lipoedema is strongly associated with obesity, the effect of bariatric surgery on thigh volume and weight loss has not been explored. <b><i>Material and Methods:<\/i><\/b> In a retrospective cohort study, thigh volume and weight loss of 31 patients with lipoedema were analyzed before and 10\u201318 and \u226519 months after sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB). Fourteen patients, with distal leg lymphoedema (i.e., with healthy thighs), who had undergone bariatric surgery served as controls. Statistical analysis was performed using a linear mixed-effects model adjusted for patient age and initial BMI. <b><i>Results:<\/i><\/b> Adjusted initial thigh volume in patients with lipoedema was 23,785.4 mL (95% confidence interval [CI] 22,316.6\u201325,254.1). Thigh volumes decreased significantly in lipoedema and control patients (baseline vs. 1st follow-up, <i>p<\/i> &#x3c; 0.0001 and <i>p<\/i> = 0.0001; baseline vs. 2nd follow-up, <i>p<\/i> &#x3c; 0.0001 and <i>p<\/i> = 0.0013). Adjusted thigh volume reduction amounted to 33.4 and 37.0% in the lipoedema and control groups at the 1st follow-up, and 30.4 and 34.7% at the 2nd follow-up, respectively (lipoedema vs. control <i>p<\/i> &#x3e; 0.999 for both). SG and RYGB led to an equal reduction in leg volume (operation type \u00d7 time, <i>p<\/i> = 0.83). Volume reduction was equally effective in obese and superobese patients (weight category \u00d7 time, <i>p<\/i> = 0.43). <b><i>Conclusion:<\/i><\/b> SG and RYGB lead to a significant thigh volume reduction in patients with lipoedema. <\/jats:p>","DOI":"10.1159\/000511044","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T21:00:32Z","timestamp":1623445232000},"page":"206-211","source":"Crossref","is-referenced-by-count":35,"title":["Leg Volume in Patients with Lipoedema following Bariatric Surgery"],"prefix":"10.1159","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6650-3490","authenticated-orcid":false,"given":"Jodok\u00a0M.","family":"Fink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Schreiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Marjanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Erbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel\u00a0J.","family":"Seifert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Foeldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Bertsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1177\/0268355516639421"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33313"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001043"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2011.153"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-966651"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2016.04.013"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12239"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1515\/hmbci-2017-0076"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-34-5-1243"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105816"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3390\/nu9050468"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2010.07504.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14289"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.64"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.3654"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12820"}],"container-title":["Visceral Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:02:56Z","timestamp":1745424176000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000511044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,22]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,6,11]]},"published-print":{"date-parts":[[2021,6,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000511044","archive":["Portico"],"relation":{},"ISSN":["2297-4725","2297-475X"],"issn-type":[{"value":"2297-4725","type":"print"},{"value":"2297-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,22]]}}}