{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:00:27Z","timestamp":1772164827651,"version":"3.50.1"},"reference-count":33,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Therapeutic hypothermia (TH) is a standard therapy for neonatal hypoxic-ischaemic encephalopathy. One potential additional therapy is the free radical scavenger edaravone (EV; 3-methyl-1-phenyl-2-pyrazolin-5-one). &lt;b&gt;&lt;i&gt;Objectives and Methods:&lt;\/i&gt;&lt;\/b&gt; This study aimed to compare the neuroprotective effects of edaravone plus therapeutic hypothermia (TH + EV) with those of TH alone after a hypoxic-ischaemic insult in the newborn piglet. Anaesthetized piglets were subjected to 40 min of hypoxia (3\u20135% inspired oxygen), and cerebral ischaemia was assessed using cerebral blood volume. Body temperature was maintained at 39.0 \u00b1 0.5\u00b0C in the normothermia group (NT, &lt;i&gt;n&lt;\/i&gt; = 8) and at 33.5 \u00b1 0.5\u00b0C (24 h after the insult) in the TH (&lt;i&gt;n&lt;\/i&gt; = 7) and TH + EV (3 mg\/kg intravenous every 12 h for 3 days after the insult; &lt;i&gt;n&lt;\/i&gt; = 6) groups under mechanical ventilation. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Five days after the insult, the mean (standard deviation) neurological scores were 10.9 (5.7) in the NT group, 17.0 (0.4) in the TH group (&lt;i&gt;p&lt;\/i&gt; = 0.025 vs. NT), and 15.0 (3.9) in the TH + EV group. The histopathological score of the TH + EV group showed no significant improvement compared with that of the other groups. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; TH + EV had no additive neuroprotective effects after hypoxia-ischaemia in neurological and histopathological assessments.<\/jats:p>","DOI":"10.1159\/000511085","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T18:00:31Z","timestamp":1603908031000},"page":"713-720","source":"Crossref","is-referenced-by-count":5,"title":["Intravenous Edaravone plus Therapeutic Hypothermia Offers Limited Neuroprotection in the Hypoxic-Ischaemic Newborn Piglet"],"prefix":"10.1159","volume":"117","author":[{"given":"Satoshi 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