{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:55:24Z","timestamp":1788602124590,"version":"build-2803163510"},"reference-count":22,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stereotact Funct Neurosurg"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Focal cortical dysplasia (FCD) is one of the most important pathogenic findings in patients with extratemporal lobe epilepsy. Magnetic resonance imaging (MRI)-negative is the most important negative factor to predict postoperative seizure freedom; however, FCD-I and part of FCD-IIa are MRI-negative on routine MRI. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; To explore the diagnostic values of 7T MRI and its new scan sequences in epilepsy patients with FCD-IIa. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; To include patients with focal seizure and suspicious focal abnormal imaging on 3T MRI during preoperative evaluation and perform a 7T MRI scan with white matter-suppressed (WMS) and gray-white matter tissue border enhancement (GWBE) sequences, resective epilepsy surgery, and postoperative pathological finding of FCD-IIa. The preoperative qualitative and localization significance of 7T MRI and 3T MRI in lesions with FCD-IIa was compared, and then, the imaging characteristics of lesions with FCD-IIa on 7T MRI were analyzed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Ten cases were enrolled in this study. Seven tesla MRI presented high spatial resolutions and a high signal-to-noise ratio. WMS and GWBE could selectively suppress the signal of special tissue and improved the possibility of FCD findings. FCD-IIa showed abnormal thickness of gray matter and a blurring border and was hypointense on 7T MRI compared with 3T MRI. Seven patients showed improvement in the qualitative diagnosis strength grade of FCD, and 6 subjects showed improvement in the localization strength grade of the lesion border after careful reading of the 7T MR images. Significant differences were found in the qualitative diagnosis of FCD (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05) and localization of the lesion border (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05) between the neuroimaging diagnoses based on 3T MRI and the findings based on 7T MRI. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; 7T MRI with WMS and GWBE sequences shows application value in the preoperative imaging diagnosis of lesions with FCD-IIa in epilepsy patients. <\/jats:p>","DOI":"10.1159\/000511152","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T22:01:09Z","timestamp":1607724069000},"page":"212-220","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Application of 7T Magnetic Resonance Imaging in Patients with Focal Cortical Dysplasia IIa and Epilepsy"],"prefix":"10.1159","volume":"99","author":[{"given":"Tinghong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilou","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaibao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangshuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuli","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,12,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02777.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13319"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1703784"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3171\/2016.8.PEDS1686"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2012.06.014"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000568"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13313"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2017.08.008"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12041"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000306"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2017.11.012"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003632"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24541"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25447"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196008"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4116"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2016.0838"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-018-3749-2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-016-0662-x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-018-2040-2"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25322"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-014-1365-8"}],"container-title":["Stereotactic 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