{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:00:30Z","timestamp":1781647230383,"version":"3.54.5"},"reference-count":29,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerontology"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> With a rapidly aging population, the need for endoscopic retrograde cholangiopancreatography (ERCP) is increasing. The commonly used sedation anesthesia in ERCP is a combination of propofol and fentanyl, even though fentanyl may cause some adverse reactions such as respiratory depression. <b><i>Objectives:<\/i><\/b> This study aimed to evaluate the efficacy of oxycodone combined with propofol versus fentanyl combined with propofol for sedation anesthesia during ERCP. <b><i>Methods:<\/i><\/b> A total of 193 patients aged from 65 to 80 years undergoing ERCP were enrolled and randomized into two groups: an \u201coxycodone combined with propofol\u201d group (group OP, <i>n<\/i> = 97) and a \u201cfentanyl combined with propofol\u201d group (group FP, <i>n<\/i> = 96). The rate of perioperative adverse events as well as the recovery time, patients\u2019 satisfaction, and endoscopists\u2019 satisfaction were noted. <b><i>Results:<\/i><\/b> There was no difference in the frequency of hypotension or bradycardia between the two groups, but there were more episodes of desaturation (SpO<sub>2<\/sub> &#x3c;90% for &#x3e;10 s in 8.3%), postoperative nausea (7.3%), and vomiting (5.2%) in group FP than in group OP. Patients\u2019 satisfaction in group FP was lower than that in group OP. The recovery time was longer in group FP than in group OP. <b><i>Conclusions:<\/i><\/b> Oxycodone combined with propofol was effective in ERCP, with a low incidence of perioperative adverse events. <\/jats:p>","DOI":"10.1159\/000511173","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T22:01:00Z","timestamp":1606860060000},"page":"9-16","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of an Oxycodone-Propofol Combination versus a Fentanyl-Propofol Combination in Conscious Sedation during Therapeutic Endoscopic Retrograde Cholangiopancreatography in Elderly Patients"],"prefix":"10.1159","volume":"67","author":[{"given":"Peipei","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huisheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,12,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0122-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-019-06966-w"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317817"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.03.002"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-019-02623-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2015.08.077"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.12756"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14860"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001347"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.771"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10322"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019004"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-007-9087-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2020.01.005"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.03.019"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1304-4"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2014.47.2.141"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.557"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1992.tb00739.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4064-y"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002966"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/465465"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccn.2004.09.003"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2019.34.e21"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21807"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.13043"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003305"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-018-1980-6"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313425"}],"container-title":["Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:04:08Z","timestamp":1745424248000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000511173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,28]]},"published-print":{"date-parts":[[2021,2,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000511173","archive":["Portico"],"relation":{},"ISSN":["0304-324X","1423-0003"],"issn-type":[{"value":"0304-324X","type":"print"},{"value":"1423-0003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,1]]}}}