{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T01:29:57Z","timestamp":1774574997480,"version":"3.50.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; We previously reported that nonsteroidal anti-inflammatory drugs (NSAIDs) induced small intestinal damage through nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome-dependent interleukin-1\u03b2 secretion in mice. Our further study demonstrated that colchicine, a therapeutic agent for gout, significantly suppressed NSAID-induced small intestinal damage by inhibiting NLRP3 inflammasome activation in mice. However, clinical efficacy of colchicine for NSAID-induced small intestinal damage has not been established. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; We examined the clinical efficacy of colchicine in patients with NSAID-induced severe small intestinal damage as an animal-to-human translational research. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This is a single-center, single-arm, prospective pilot study. From February 2017 to March 2019, we performed video capsule endoscopy (VCE) to screen 10 patients who took NSAIDs continuously for more than 3 months, and 7 of those with severe small intestinal damage were enrolled. Participants were treated with oral colchicine 0.5 mg twice daily for 8 weeks and thereafter followed up with blood tests and VCE. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; After 8 weeks of colchicine treatment, complete healing was achieved in 4 patients (57.1%), and the median number of small erosions decreased significantly from 7.0 (range, 5.0\u201310.5) to 0.0 (range, 0.0\u20132.3) (&lt;i&gt;p&lt;\/i&gt; = 0.031). One patient withdrew due to diarrhea, and 5 patients revealed slightly elevated liver enzymes during the study. No other adverse events including changes in blood tests and clinical symptoms were observed. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Colchicine treatment achieved a high rate of complete healing in patients with NSAID-induced severe small intestinal damage. <\/jats:p>","DOI":"10.1159\/000511255","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T22:14:16Z","timestamp":1605651256000},"page":"803-808","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Colchicine on NSAID-Induced Severe Small Intestinal Damage: A Pilot Study"],"prefix":"10.1159","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9075-6415","authenticated-orcid":false,"given":"Koji","family":"Otani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8567-0585","authenticated-orcid":false,"given":"Toshio","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Higashimori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Nadatani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Nagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Taira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Inui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s1542-3565(04)00619-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/s1542-3565(04)00603-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.03.020"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2012.12.005"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197410312911804"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197410312911803"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(75)80031-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(77)92945-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.121028"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.117.12.760"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/BF00403737"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04674.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198612043152304"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.89"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/srep32587"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-304713"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.06.056"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000452356"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-019-01657-8"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2016.05.006"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511255","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:05:05Z","timestamp":1745424305000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000511255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,17]]},"references-count":20,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,9,1]]},"published-print":{"date-parts":[[2021,9,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000511255","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,17]]}}}