{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:32:25Z","timestamp":1747193545245,"version":"3.40.5"},"reference-count":17,"publisher":"S. Karger AG","issue":"12","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> Assessment of intrinsic dynamic positive end-expiratory pressure (PEEPi,dyn) may be clinically important in stable patients with chronic obstructive pulmonary disease (COPD), but epidemiological data are scant. <b><i>Objectives:<\/i><\/b> The aim of our study was (i) to assess the PEEPi,dyn in a large population of stable patients with COPD and (ii) to evaluate the correlations with some noninvasive measurements routinely assessed. <b><i>Method:<\/i><\/b> Retrospective analysis of lung mechanics, dynamic volumes, arterial blood gases, dyspnoea by means of the Medical Research Council (MRC) scale, the COPD Assessment Test score, and maximal inspiratory\/expiratory pressures in 87 hypercapnic and 62 normocapnic patients. <b><i>Results:<\/i><\/b> The mean PEEPi,dyn was significantly higher in hypercapnic than normocapnic patients (2.8 \u00b1 2.2 vs. 1.9 \u00b1 1.6 cm H<sub>2<\/sub>O, respectively, <i>p<\/i> = 0.0094). PEEPi,dyn did not differ according to Global Initiative for Chronic Obstructive Lung Disease stage, MRC score, or use or not of long-term oxygen therapy. There were significant although weak correlations between PEEPi,dyn and airway obstruction, hyperinflation, respiratory muscle function, arterial CO<sub>2<\/sub> tension, and number of exacerbations\/year. The transdiaphragmatic pressure was the strongest variable associated to PEEPi,dyn (<i>R<\/i> = 0.5713, <i>p<\/i> = 0.001). <b><i>Conclusion:<\/i><\/b> In stable patients with COPD, PEEPi,dyn is higher in hypercapnic patients and weakly correlated to noninvasive measures of lung and respiratory muscle function. <\/jats:p>","DOI":"10.1159\/000511266","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T22:01:32Z","timestamp":1607032892000},"page":"1129-1135","source":"Crossref","is-referenced-by-count":3,"title":["Intrinsic Dynamic Positive End-Expiratory Pressure in Stable Patients with Chronic Obstructive Pulmonary Disease"],"prefix":"10.1159","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9389-7915","authenticated-orcid":false,"given":"Michele","family":"Vitacca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Ceriana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2709-919X","authenticated-orcid":false,"given":"Irene","family":"Prediletto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Carlucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara","family":"Paneroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolino","family":"Ambrosino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Nava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/143.5_Pt_1.905"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1982.126.1.166"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.5_Pt_1.1194"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2002.1459"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01003-2019"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.pulmoe.2019.07.006"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00102509"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.166.4.518"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/146.3.790"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.4.7697242"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.5.8173743"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.2.7842221"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.10.847"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.5.1286"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.9805011"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-001-1113-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.4.990"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511266","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:05:12Z","timestamp":1745424312000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000511266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":17,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,1,18]]},"published-print":{"date-parts":[[2021,2,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000511266","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"type":"print","value":"0025-7931"},{"type":"electronic","value":"1423-0356"}],"subject":[],"published":{"date-parts":[[2020]]}}}