{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:39:04Z","timestamp":1792071544653,"version":"4.4.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digit Biomark"],"abstract":"<b><i>Objective:<\/i><\/b> Differentiating benign from dangerous causes of dizziness or vertigo presents a major diagnostic challenge for many clinicians. Bedside presentations of peripheral vestibular disorders and posterior fossa strokes are often indistinguishable other than by a few subtle vestibular eye movements. The most challenging of these to interpret is the head impulse test (HIT) of vestibulo-ocular reflex (VOR) function. There have been major advances in portable video-oculography (VOG) quantification of the video HIT (vHIT), but these specialized devices are not routinely available in most clinical settings. As a first step towards smartphone-based diagnosis of strokes in patients presenting vestibular symptoms, we sought proof of concept that we could use a smartphone application (\u201capp\u201d) to accurately record the vHIT. <b><i>Methods:<\/i><\/b> This was a cross-sectional agreement study comparing a novel index test (smartphone-based vHIT app) to an accepted reference standard test (VOG-based vHIT) for measuring VOR function. We recorded passive (examiner-performed) vHIT sequentially with both methods in a convenience sample of patients visiting an otoneurology clinic. We quantitatively correlated VOR gains (ratio of eye to head movements during the HIT) from each side\/ear and experts qualitatively assessed the physiologic traces by the two methods. <b><i>Results:<\/i><\/b> We recruited 11 patients; 1 patient\u2019s vHIT could not be reliably quantified with either device. The novel and reference test VOR gain measurements for each ear (<i>n<\/i> = 20) were highly correlated (Pearson\u2019s <i>r<\/i> = 0.9, <i>p<\/i> = 0.0000001) and, qualitatively, clinically equivalent. <b><i>Conclusions:<\/i><\/b> This preliminary study provides proof of concept that an \u201ceyePhone\u201d app could be used to measure vHIT and eventually developed to diagnose vestibular strokes by smartphone.<\/jats:p>","DOI":"10.1159\/000511287","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T17:02:21Z","timestamp":1609347741000},"page":"1-8","source":"Crossref","is-referenced-by-count":44,"title":["Proof of Concept for an \u201ceyePhone\u201d App to Measure Video Head Impulses"],"prefix":"10.1159","volume":"5","author":[{"given":"T.\u00a0Maxwell","family":"Parker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Farrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Otero-Millan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Kheradmand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayodele","family":"McClenney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0E.","family":"Newman-Toker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,12,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003814"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24532"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.100174"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/acem.12223"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2015.7.26158"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1564298"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.026505"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.03.002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000362780"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3233\/VES-160587"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2014.01.024"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3766\/jaaa.16138"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2015.015"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000033"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007644"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.2.290"}],"container-title":["Digital Biomarkers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:05:32Z","timestamp":1745409932000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000511287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,30]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,4,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000511287","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.13502487","asserted-by":"subject"}]},"ISSN":["2504-110X"],"issn-type":[{"value":"2504-110X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,30]]}}}