{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:54:34Z","timestamp":1785498874345,"version":"3.56.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Aim:<\/i><\/b> To describe the demographic characteristics, risk factors, and presenting features of children with symptomatic nutritional rickets in France. <b><i>Methods:<\/i><\/b> This is a retrospective study of 38 children diagnosed with nutritional rickets from 1998 to 2019. <b><i>Results:<\/i><\/b> We observed a higher frequency of rickets in males (74 vs. 26%), in young children (median age at diagnosis: 23 months; 82% were younger than 5 years), and in children with a non-Caucasian ethnic background (89%). Most children were exclusively breastfed (78%) without adequate vitamin D supplementation (89%). The most common presentations were bowed legs (63%), hypocalcemic seizures (21%), and growth retardation (11%). Approximately half (62%) of the children were hypocalcemic. The children presenting with hypocalcemic seizures were significantly younger (0.8 vs. 2.2 years; <i>p<\/i> = 0.041) and had lower total serum calcium levels (1.44 vs. 2.17 mmol\/L; <i>p<\/i> &#x3c; 0.0001), higher phosphatemia (1.43 vs. 1.23 mmol\/L; <i>p<\/i> = 0.020), and lower 25-hydroxy vitamin D levels (3 vs. 7 ng\/mL; <i>p<\/i> = 0.020) but similar parathyroid hormone levels (357 vs. 289 ng\/mL; <i>p<\/i> = 0.940) compared to rickets cases who did not experience hypocalcemic seizures. A dilated cardiomyopathy was detected in 14% of the children who had undergone echocardiography. <b><i>Conclusion:<\/i><\/b> Nutritional rickets remains endemic in the pediatric population and its most severe forms can have life-threatening sequelae. Health practitioners need to be cognizant of these facts to raise awareness and screen high-risk populations. <\/jats:p>","DOI":"10.1159\/000511419","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T22:00:31Z","timestamp":1604008831000},"page":"304-312","source":"Crossref","is-referenced-by-count":20,"title":["Demographic Characteristics, Risk Factors, and Presenting Features of Children with Symptomatic Nutritional Rickets: A French Series"],"prefix":"10.1159","volume":"93","author":[{"given":"Claire","family":"Flot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Porquet-Bordes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Bacchetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anya","family":"Rothenbuhler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Lienhardt-Roussie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloise","family":"Giabicani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iva","family":"Gueorguieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Storey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Linglart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Salles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9222-5009","authenticated-orcid":false,"given":"Thomas","family":"Edouard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.101"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2012.11.018"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2011.12.015"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0818"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60211-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.061377"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14835"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.095075"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2175"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2014.04.012"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)12331-5"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2773"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.069575"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2003.tb00475.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.173195"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.031385"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200x.2000.01230.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-011-9200-6"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.119792"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s002469900464"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2003.05.002"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2015.03.003"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:07:13Z","timestamp":1745424433000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000511419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,12,8]]},"published-print":{"date-parts":[[2021,2,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000511419","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}