{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:10:20Z","timestamp":1780611020110,"version":"3.54.1"},"reference-count":26,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To investigate the expression of T-cell immunoglobulin and mucin domain 3 (TIM-3) on peripheral T cells of cervical carcinoma patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Peripheral blood samples from 15 high-grade cervical squamous intraepithelial lesion (HSIL) patients, 24 cervical carcinoma patients, and 21 healthy controls were collected. TIM-3 expressions on the surface of peripheral CD4+ T cells and CD8+ T cells were analyzed with flow cytometry. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; There was significantly lower expression of CD4+ T cells and CD8+ T cells in HSIL patients and cervical carcinoma patients compared with healthy controls. We also found that TIM-3 expression on peripheral CD4+ T and CD8+ T cells of both HSIL patients and cervical carcinoma patients was significantly increased compared to the control group. Further analyses revealed that the expression of TIM-3 on peripheral CD4+ T and CD8+ T cells significantly increased in stage III\u2013IV cervical carcinoma patients compared to stages I\u2013II. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The increased expression of TIM-3 on CD4+ T cells and CD8+ T cells of patients with cervical carcinoma and HSIL suggests the potential role of TIM-3 in the development and progression of cervical carcinoma, which may be a novel therapy target for cervical carcinoma. <\/jats:p>","DOI":"10.1159\/000511440","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T22:07:49Z","timestamp":1607119669000},"page":"63-70","source":"Crossref","is-referenced-by-count":2,"title":["Elevated Expression of T-Cell Immunoglobulin and Mucin Domain 3 on T Cells from Peripheral Blood in Patients with Cervical Carcinoma"],"prefix":"10.1159","volume":"86","author":[{"given":"Juan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-fei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-yan","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31166"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2016.08.001"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S131309"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20779-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2018.04.001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/415536a"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.4774"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0000000000000122"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12520"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11611"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-015-1752-y"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000882"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10719-012-9379-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2015.02.008"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/nature14468"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00475"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00639-09"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939842"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8657"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1712107115"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2871"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053834"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009731107"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100637"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2017_112"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511440","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:07:22Z","timestamp":1745424442000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000511440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,4]]},"references-count":26,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2021,5,20]]},"published-print":{"date-parts":[[2021,5,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000511440","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,4]]}}}