{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T10:44:25Z","timestamp":1780742665286,"version":"3.54.1"},"reference-count":23,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:00:00Z","timestamp":1607472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:00:00Z","timestamp":1607472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["GE Port J Gastroenterol"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Peroral endoscopic myotomy (POEM) is an innovative achalasia treatment procedure that involves myotomy of the lower esophageal sphincter through a submucosal tunneling approach, combining the efficacy of surgical myotomy with the benefit of being a less invasive treatment. At this time, no data are available of POEM in Portugal. This study aimed to examine the safety and short-term outcomes of POEM in a Portuguese center. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Fifty POEM were performed on 49 consecutive patients at our institution between January 2017 and January 2020. A prospective study of a consecutive series of patients was conducted, including procedure time, myotomy location and length, adverse events and clinical success. An Eckardt score of \u22643 after POEM was deemed as a successful outcome. Gastroesophageal reflux disease (GERD) was evaluated based on symptoms and on upper endoscopy, which was performed at 3\u20136 months postoperatively to check for reflux esophagitis. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; POEM was successfully completed in all cases: 70% (&lt;i&gt;n&lt;\/i&gt; = 35) were na\u00efve and 30% (&lt;i&gt;n&lt;\/i&gt; = 15) had previous treatments. The mean procedure time was 73.4 \u00b1 22.6 min (range 45\u2013125 min). There were no major adverse events. Minor adverse events were rare (8%), and there was no perioperative mortality. The Eckardt score significantly decreased from 6.9 \u00b1 2.4 preoperatively to 0.5 \u00b1 1.0 postoperatively (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05). Overall clinical success was documented in 98, 98 and 95.2% at 1, 3 and 6 months, respectively. These short-term outcomes after POEM were independent of previous treatments. Symptomatic GERD was seen in 22.4% of patients. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Our results confirm the safety and excellent short-term efficacy of POEM in a Portuguese center. This supports POEM as one of the first-line achalasia therapies in Portugal when performed by experienced operators. <\/jats:p>","DOI":"10.1159\/000511528","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T22:18:23Z","timestamp":1607552303000},"page":"162-169","source":"Crossref","is-referenced-by-count":4,"title":["Peroral Endoscopic Myotomy for Esophageal Achalasia in Portugal: Outcomes of the First Prospective Series"],"prefix":"10.1159","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6641-2647","authenticated-orcid":false,"given":"Rui","family":"Mendo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Barreiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"F\u00e9lix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"O'Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iala","family":"Carina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Chivia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Chagas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,12,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Khashab MA, Vela MF, Thosani N, Agrawal D, Buxbaum JL, Abbas Fehmi SM, et al. ASGE guideline on the management of achalasia. Gastrointest Endosc. 2020 Feb;91(2):213\u2013227.e6.","DOI":"10.1016\/j.gie.2019.04.231"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Richter JE. Oesophageal motility disorders. Lancet. 2001 Sep;358(9284):823\u20138.","DOI":"10.1016\/S0140-6736(01)05973-6"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Kahrilas PJ, Bredenoord AJ, Carlson DA, Pandolfino JE. Advances in Management of Esophageal Motility Disorders. Clin Gastroenterol Hepatol. 2018 Nov;16(11):1692\u2013700.","DOI":"10.1016\/j.cgh.2018.04.026"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Werner YB, Hakanson B, Martinek J, Repici A, von Rahden BH, Bredenoord AJ, et al. Endoscopic or Surgical Myotomy in Patients with Idiopathic Achalasia. N Engl J Med. 2019 Dec;381(23):2219\u201329.","DOI":"10.1056\/NEJMoa1905380"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Kahrilas PJ, Katzka D, Richter JE. 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