{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:27:05Z","timestamp":1792549625956,"version":"4.5.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> Phenobarbitone induces suppression of cerebral electrical activity on amplitude-integrated electroencephalography (aEEG) in neonates with hypoxic-ischemic encephalopathy (HIE); however, its effect during therapeutic hypothermia (TH) has not been well characterized. <b><i>Objective:<\/i><\/b> To evaluate the effect of phenobarbitone on aEEG in neonates with HIE undergoing TH. <b><i>Methods:<\/i><\/b> Thirty-five neonates born at \u226535<sup>0<\/sup> weeks gestational age (GA), who received phenobarbitone as first-line antiepileptic drug during TH for \u2265 Sarnat stage II HIE with aEEG recordings were retrospectively studied. Background pattern, upper and lower margin voltages were characterized for a 30-min period before and 30\u201360 min after phenobarbitone administration. Primary outcome was presence of severely abnormal aEEG pattern after phenobarbitone administration. <b><i>Results:<\/i><\/b> Mean (\u00b1SD) GA and median birth weight were 38.2 \u00b1 1.9 weeks and 3.1 (2.5\u20133.9) kg, respectively. Phenobarbitone (10\u201320 mg\/kg), administered at median age 16.8 h, was associated with background pattern worsening in 19\/29 (65.5%) cases. Severe background patterns were more prevalent in post- versus pre-phenobarbitone tracings (21\/29 [72%] vs. 11\/29 [38%]; <i>p<\/i> = 0.01). Presence of severe pattern versus either continuous normal voltage or discontinuous normal voltage pattern post-phenobarbitone, (20\/25 [80%] vs. 3\/8 [38%]; <i>p<\/i> = 0.036) was associated with death or moderate-to-severe injury on MRI brain. Median time to trace recovery, when measurable, was 4 h (45 min\u201372 h). <b><i>Conclusions:<\/i><\/b> Phenobarbitone induces significant suppression on aEEG in infants with HIE undergoing TH. Development of severe aEEG background patterns after phenobarbitone may unmask a population at greater risk of abnormal outcome. <\/jats:p>","DOI":"10.1159\/000511540","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T22:01:10Z","timestamp":1610056870000},"page":"721-728","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Phenobarbitone on Amplitude-Integrated Electroencephalography in Neonates with Hypoxic-Ischemic Encephalopathy during Hypothermia"],"prefix":"10.1159","volume":"117","author":[{"given":"Poorva","family":"Deshpande","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amish","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.58.12.997"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-301524"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.6.1263"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/fn.81.1.f19"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000127019.52562.8c"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.064964"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2005.06.018"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807306258"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1839"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-2036"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1297"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2938"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2005.06.018"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1993.tb12511.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1839"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2008.08.005"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1297"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01653.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-301524"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-012-0004-y"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1993.tb12511.x"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511540","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:08:05Z","timestamp":1745424485000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000511540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":21,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,2,9]]},"published-print":{"date-parts":[[2021,2,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000511540","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}