{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:11:39Z","timestamp":1778317899793,"version":"3.51.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Newborn sudden infant death syndrome (SIDS) has failed to decrease in the last decades, and a third of the neonatal cases occurred within the first 6 days of life. The long QT syndrome (LQTS) is a genetic disease with a prevalence of 1 in 2,000 live births and contributes to almost 10% of SIDS cases. Early identification of LQTS through electrocardiogram (ECG) screening is likely to reduce mortality. &lt;b&gt;&lt;i&gt;Methods and Results:&lt;\/i&gt;&lt;\/b&gt; In this ongoing prospective study we evaluated 2,251 ECGs from newborns participating in the KUNO Kids birth cohort study between July 2015 and July 2018. ECGs were recorded at a mean age of 2.0 days (IQR 0 days). The QT interval was corrected for heart rate using Bazett\u2019s formula (QTc). A QTc between 451 and 460, 461\u2013470, and &amp;#x3e;470 ms was measured in 23 (1.0), 14 (0.6), and 62 (2.8%) participants, respectively. Fourteen neonates (0.62%) were admitted and monitored because their initial QTc was \u2265500 ms. In 2 genetically analyzed participants, a mutation was found. One disease-causing for LQTS type 1 and the other of unclear significance. Cascade screening revealed affected members in both families. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; A standardized neonatal ECG screening in the first days of life is able to identify neonates with a relevant transient form of prolonged QT intervals and to aid diagnosing congenital LQTS. <\/jats:p>","DOI":"10.1159\/000511572","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T22:00:44Z","timestamp":1605218444000},"page":"756-763","source":"Crossref","is-referenced-by-count":17,"title":["Electrocardiographic Screening in the First Days of Life for Diagnosing Long QT Syndrome: Findings from a Birth Cohort Study in Germany"],"prefix":"10.1159","volume":"117","author":[{"given":"Alexander","family":"Simma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Potapow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Brandstetter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Michel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4194-0758","authenticated-orcid":false,"given":"Michael","family":"Melter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Seelbach-G\u00f6bel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Apfelbacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kabesch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Gerling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the KUNO Kids Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199806113382401"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.658021"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.010"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.101.6.616"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.863209"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.056"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.103.1.89"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000619"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl115"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.063"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.09.047"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2005.02.011"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.661082"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.66.3.496"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0643"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s40348-018-0088-z"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.03.037"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0188-7"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2002.3274"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy284"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(63)90066-8"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.003859"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00399-012-0230-x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3181d86525"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511572","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:08:15Z","timestamp":1745424495000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000511572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,2,9]]},"published-print":{"date-parts":[[2021,2,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000511572","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}