{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T06:57:38Z","timestamp":1782025058229,"version":"3.54.5"},"reference-count":29,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Care"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> The aim of this study was to compare the risk of complications and recurrence between oncoplastic and conventional breast surgery. <b><i>Methods:<\/i><\/b> This is a retrospective analysis of a consecutive series of 436 patients with stage I\u2013III breast cancer who underwent surgery at the University Hospital of Basel between 2011 and 2018. <b><i>Results:<\/i><\/b> The nipple\/skin-sparing mastectomy (NSM\/SSM) group showed significantly more delayed wound healing (32.7 vs. 5.8%, <i>p<\/i> &#x3c; 0.001) and skin necrosis (13.9 vs. 1.9%, <i>p<\/i> = 0.020) compared to conventional mastectomy (CM), which corresponded to significantly higher odds of short-term complications (OR 2.34, 95% CI 1.02\u20135.35, <i>p<\/i> = 0.044). The incidence rate of long-term morbidity in oncoplastic breast-conserving surgery (OBCS) was significantly higher compared to conventional breast-conserving surgery (CBCS; 25.5 vs. 11.3 per 100 patient years [PY], <i>p<\/i> &#x3c; 0.001), in particular concerning chronic pain (13.3 vs. 6.6, <i>p<\/i> = 0.011) and lymphedema (4.1 vs. 0.4, <i>p<\/i> = 0.003). Seroma as a long-term morbidity occurred more often in the CM group compared to the NSM\/SSM group (5.8 vs. 0.5 per 100 PY, <i>p<\/i> = 0.004). Patients received adjuvant treatment earlier after CM compared to NSM\/SSM (HR 1.83, 95% CI 1.05\u20133.19, <i>p<\/i> = 0.034). There were no significant differences in the incidence of positive margins nor in the odds of recurrence after OBCS versus CBCS and after NSM\/SSM versus CM. <b><i>Conclusions:<\/i><\/b> Even though the present study confirmed expected differences in complications and morbidity, it suggested that oncoplastic surgery is oncologically safe. Patients undergoing NSM\/SSM should be followed closely to allow early detection and treatment of frequently associated complications and ensure timely start of adjuvant therapy. <\/jats:p>","DOI":"10.1159\/000511728","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T22:00:32Z","timestamp":1606341632000},"page":"452-460","source":"Crossref","is-referenced-by-count":22,"title":["Impact of Oncoplastic Breast Surgery on Rate of Complications, Time to Adjuvant Treatment, and Risk of 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