{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:08:00Z","timestamp":1773281280124,"version":"3.50.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"11","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Bronchoscopy with bronchoalveolar lavage (BAL) during the SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) pandemic should be reserved to a limited number of clinical indications. The yield of BAL for the diagnosis of suspected or confirmed pulmonary SARS-CoV-2 infection is still unknown. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; We aimed to evaluate the diagnostic ratio of BAL in detecting SARS-CoV-2 pulmonary infection in patients undergoing bronchoscopy for different indications as well as describe the clinical, radiological, and endoscopic characteristics of patients with SARS-CoV-2 on BAL. &lt;b&gt;&lt;i&gt;Method:&lt;\/i&gt;&lt;\/b&gt; We conducted a multicenter retrospective study including all patients who underwent bronchoscopy for the detection of SARS-CoV-2 on BAL. Clinical, computed tomography (CT), endoscopic, and microbiologic data were gathered from March 16th to May 27th, 2020. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; 131 patients were included. Bronchoscopy was performed for suspected SARS-CoV-2 infection (65.5%), alternative diagnosis (12.9%), suspected superinfections (19.8%), and lung atelectasis (1.5%). SARS-CoV-2 was isolated on BAL 43 times (32.8%) and the highest isolation rate was in patients with suspected SARS-CoV-2 infection (74.4%); 76% of positive patients had a double-negative nasopharyngeal swab. Peripheral, posterior and multilobar CT opacities were more frequent in SARS-CoV-2 patients, and the number of CT findings was higher in positive patients, particularly those with suspected SARS-CoV-2 infection. We recorded a progressive reduction of SARS-CoV-2 isolation during the observation period. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; In our centers, the rate of detection of SARS-CoV-2 on BAL in patients with suspected infection was 37.2%. The agreement of BAL with nasopharyngeal swabs was high; CT alterations could predict the pretest probability of SARS-CoV-2 infection, but suspicion of viral infection should be always considered. <\/jats:p>","DOI":"10.1159\/000511964","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T21:00:31Z","timestamp":1603141231000},"page":"970-978","source":"Crossref","is-referenced-by-count":51,"title":["SARS-CoV-2 Detection on Bronchoalveolar Lavage: An Italian Multicenter experience"],"prefix":"10.1159","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4794-8734","authenticated-orcid":false,"given":"Filippo","family":"Patrucco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Albera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Bellocchia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Foci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Gavelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi\u00a0Mario","family":"Castello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Bellan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier\u00a0Paolo","family":"Sainaghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Airoldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero\u00a0Emilio","family":"Balbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3972-2871","authenticated-orcid":false,"given":"Paolo","family":"Solidoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,10,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000507898"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000045"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2015897"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.108961"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13824"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000681"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.04.036"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202004-0945LE"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00140"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2005492"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.105155"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2016.07.011"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.3786"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.7326\/M20-1495"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01733-2020"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202004-1278IM"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/RTI.0000000000000524"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020201473"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01619-2020"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511964","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:12:09Z","timestamp":1745424729000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000511964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":20,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,1,12]]},"published-print":{"date-parts":[[2021,1,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000511964","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}