{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:30:29Z","timestamp":1747193429890,"version":"3.40.5"},"reference-count":12,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Dermatol"],"abstract":"<jats:p>Here, we report two cases of cutaneous adverse effects possibly induced by the use of tumor necrosis factor-alpha (TNF-\u03b1) inhibitors. The first case presented alopecia areata (AA) and atopic dermatitis (AD) that developed during the treatment of ulcerative colitis using infliximab; the other case presented urticaria and AD that developed during the treatment of rheumatoid arthritis using etanercept. AA, AD, and urticaria are relatively common skin diseases; however, they are not well known as adverse effects of TNF-\u03b1 inhibitors. Although immunological studies were not performed, the clinical courses suggested that these skin disorders might have developed as a result of an immune four-way imbalance in T helper 1 (Th1), Th2, Th17, and regulatory T cells by the administration of TNF-\u03b1 inhibitors. <\/jats:p>","DOI":"10.1159\/000511985","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T21:32:34Z","timestamp":1618867954000},"page":"238-243","source":"Crossref","is-referenced-by-count":2,"title":["Two Cases of Cutaneous Adverse Effects Induced by Tumor Necrosis Factor-Alpha Inhibitors"],"prefix":"10.1159","volume":"13","author":[{"given":"Ena","family":"Masukawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Matsushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Habe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3055-5202","authenticated-orcid":false,"given":"Keiichi","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02719.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.10.016"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302853"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0001-z"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132710"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12808"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-018-1823-y"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000499030"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2019.10.012"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.06.032"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3645"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2008.01601.x"}],"container-title":["Case Reports in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511985","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/511985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:12:33Z","timestamp":1745424753000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000511985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,19]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,5,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000511985","archive":["Portico"],"relation":{},"ISSN":["1662-6567"],"issn-type":[{"type":"electronic","value":"1662-6567"}],"subject":[],"published":{"date-parts":[[2021,4,19]]}}}