{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:30:30Z","timestamp":1747193430096,"version":"3.40.5"},"reference-count":28,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Complement Med Res"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>Background: Vitamin D has been shown to be associated with reduced risk and severity of COVID-19 and exerts regulating effects on all hallmarks of cancer. The goal of this study was to analyze the vitamin D status of a cancer patient cohort from our clinic in the Franconian region, Germany. Methods: 25-hydroxyvitamin D concentrations were available for 116 patients included in prospective trials in our clinic. Associations of vitamin D with anthropometric and blood parameters were investigated using Kendall\u2019s \u03c4 correlation coefficients and linear regression. Results: A total of 57 patients (49.1%) were vitamin D deficient (&lt;20 ng\/mL), and 92.2% did not meet the recommended vitamin D level of 40 ng\/mL. There was a strong negative association between vitamin D and leukocyte count (\u03c4 = \u20130.173, p = 0.007) and C-reactive protein concentration (\u03c4 = \u20130.172, p = 0.007). In linear regression, the most important variables for predicting vitamin D levels were (in order of decreasing importance) season, fat mass index, platelet, and leukocyte count. Conclusions: Despite appeals towards medical societies to target widespread vitamin D deficiency in Germany more than 10 years ago, our data indicate that these have been without avail. Low vitamin D levels in cancer patients should be corrected using reasonable sun exposure and supplements. <\/jats:p>","DOI":"10.1159\/000511993","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T22:00:57Z","timestamp":1607983257000},"page":"300-307","source":"Crossref","is-referenced-by-count":3,"title":["Low Vitamin D Status in a Cancer Patient Population from Franconia, Germany"],"prefix":"10.1159","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1401-4270","authenticated-orcid":false,"given":"Rainer\u00a0Johannes","family":"Klement","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra\u00a0S.","family":"Koebrunner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelley","family":"Krage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhart\u00a0A.","family":"Sweeney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04261.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24699"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2018.1540904"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15752"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2020-0213"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2020.04.001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2015.11.001"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2019.03.007"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081747"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-017-0189-z"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10260-010-0142-z"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v033.i01"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2007.12.001"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/nu12040988"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4161\/derm.26738"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051359"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092757"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3691"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1547572"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.17886\/RKI-GBE-2016-036"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1080\/10245332.2017.1318334"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020474"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-018-3092-3"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2017.06.003"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.98038"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/BF02555135"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.3.690"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200900494"}],"container-title":["Complementary Medicine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cmr\/article-pdf\/28\/4\/300\/3908992\/000511993.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cmr\/article-pdf\/28\/4\/300\/3908992\/000511993.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:12:39Z","timestamp":1745424759000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000511993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,14]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,8,24]]},"published-print":{"date-parts":[[2021,8,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000511993","archive":["Portico"],"relation":{},"ISSN":["2504-2092","2504-2106"],"issn-type":[{"type":"print","value":"2504-2092"},{"type":"electronic","value":"2504-2106"}],"subject":[],"published":{"date-parts":[[2020,12,14]]}}}