{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T11:52:52Z","timestamp":1772711572233,"version":"3.50.1"},"reference-count":17,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; There is still no clinical evidence available to support or to oppose corticosteroid treatment for coronavirus disease 2019 (COVID-19) pneumonia. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To investigate the efficacy and safety of corticosteroid given to the hospitalized patients with COVID-19 pneumonia. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This was a prospective, multicenter, single-blind, randomized control trial. Adult patients with COVID-19 pneumonia who were admitted to the general ward were randomly assigned to either receive methylprednisolone or not for 7 days. The primary end point was the incidence of clinical deterioration 14 days after randomization. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; We terminated this trial early because the number of patients with COVID-19 pneumonia in all the centers decreased in late March. Finally, a total of 86 COVID-19 patients underwent randomization. There was no difference of the incidence of clinical deterioration between the methylprednisolone group and control group (4.8 vs. 4.8%, &lt;i&gt;p&lt;\/i&gt; = 1.000). The duration of throat viral RNA detectability in the methylprednisolone group was 11 days (interquartile range, 6\u201316 days), which was significantly longer than that in the control group (8 days [2\u201312 days], &lt;i&gt;p&lt;\/i&gt; = 0.030). There were no significant differences between the 2 groups in other secondary outcomes. Mass cytometry discovered CD3&lt;sup&gt;+&lt;\/sup&gt; T cells, CD8&lt;sup&gt;+&lt;\/sup&gt; T cells, and NK cells in the methylprednisolone group which were significantly lower than those in the control group after randomization (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; From this prematurely closed trial, we found that the short-term early use of corticosteroid could suppress the immune cells, which may prolong severe acute respiratory syndrome coronavirus 2 shedding in patients with COVID-19 pneumonia. &lt;b&gt;&lt;i&gt;Trial Registration:&lt;\/i&gt;&lt;\/b&gt; ClinicalTrials.gov, NCT04273321. <\/jats:p>","DOI":"10.1159\/000512063","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T22:01:36Z","timestamp":1611352896000},"page":"116-126","source":"Crossref","is-referenced-by-count":101,"title":["Early Use of Corticosteroid May Prolong SARS-CoV-2 Shedding in Non-Intensive Care Unit Patients with COVID-19 Pneumonia: A Multicenter, Single-Blind, Randomized Control 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