{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:27:02Z","timestamp":1792650422499,"version":"4.5.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; According to guidelines, it is possible to biopsy lung tumors \u201cimmediately adjacent to the esophagus\u201d with EUS-B-FNA. However, it is unknown what \u201cimmediately adjacent\u201d exactly means. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; to investigate the possibility of achieving EUS-B-FNA biopsies from a lung tumor depending on the distance from the esophagus and to establish the maximal allowable distance between the tumor and the esophagus. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; In a prospective observational study, we included patients with a lung tumor located maximum 6 cm from the esophagus and indication of EUS-B-FNA from the tumor. The tumors were of different sizes. In a plot presenting the tumor size-distance relationship in cases with (biopsy) versus without (non-biopsy) successful EUS-B-FNA, a separation line representing the threshold between the groups were identified and a biopsy-index equation established. The maximal tumor-size corrected distance (TSCD) was calculated using the residuals to the separation line. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In total, 70 patients were included. EUS-B-FNA from the lung tumor was possible in 46 patients. All tumors with a distance from the esophagus below 19 mm could be biopsied. The maximal allowable esophagus-tumor distance depended on tumor size. From the separation line, a biopsy-index equation was established with the sensitivity of 93.5%, a specificity of 100%, and total accuracy of 95.7%. The TSCD was 31 mm (sensitivity: 95.7%, specificity 75.0%, and accuracy: 88.6%). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; We established a biopsy-index equation to predict the achievability of a lung tumor using EUS-B-FNA depending on distance to esophagus and tumor size. A general maximal TSCD was 31 mm.<\/jats:p>","DOI":"10.1159\/000512074","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T17:00:41Z","timestamp":1611248441000},"page":"135-144","source":"Crossref","is-referenced-by-count":6,"title":["Characterization of Lung Tumors that the Pulmonologist can Biopsy from the Esophagus with Endosonography (EUS-B-FNA)"],"prefix":"10.1159","volume":"100","author":[{"given":"Ida Skovgaard","family":"Christiansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Bo S\u00f8ndergaard","family":"Svendsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1231-9209","authenticated-orcid":false,"given":"Uffe","family":"Bodtger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatinder Singh","family":"Sidhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafi","family":"Nessar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran Nadir","family":"Salih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asbj\u00f8rn","family":"H\u00f8egholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Frost","family":"Clementsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1392040"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1759-7714.2010.00003.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/150492"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.06.007"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5107(04)01680-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5107(05)01499-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31802fc1cf"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2010.05266.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s1590-8658(13)60210-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2004.11.017"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/2303-9027.151332"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000350"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000492578"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0b013e31829182a0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01102-2017"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1309892"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1109\/72.991427"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1023\/b:stco.0000035301.49549.88"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/s0004-9514(08)70022-9"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7458.168"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2307\/2987937"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205285"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:13:50Z","timestamp":1745410430000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,23]]},"published-print":{"date-parts":[[2021,2,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000512074","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}