{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T06:38:11Z","timestamp":1793342291398,"version":"4.5.0"},"reference-count":68,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T00:00:00Z","timestamp":1607385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T00:00:00Z","timestamp":1607385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to identify the rates of 2 phenotypes of intra-amniotic inflammation: intra-amniotic infection (with microbial invasion of the amniotic cavity [MIAC]) and sterile intra-amniotic inflammation (without MIAC), and their outcomes, among women with cervical insufficiency with prolapsed fetal membranes. &lt;b&gt;&lt;i&gt;Methods of Study:&lt;\/i&gt;&lt;\/b&gt; This is a retrospective study of women admitted to the Department of Obstetrics and Gynecology, University Hospital Hradec Kralove between January 2014 and May 2020. Transabdominal amniocentesis to evaluate intra-amniotic inflammation (amniotic fluid interleukin-6) and MIAC (culturing and molecular biology methods) was performed as part of standard clinical management. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In total, 37 women with cervical insufficiency and prolapsed fetal membranes were included; 11% (4\/37) and 43% (16\/37) of them had intra-amniotic infection and sterile intra-amniotic inflammation, respectively. In women with intra-amniotic infection and sterile intra-amniotic inflammation, we noted shorter intervals between admission and delivery (both &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.0001), and lower gestational age at delivery (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.0001 and &lt;i&gt;p&lt;\/i&gt; = 0.004) and percentiles of birth\/abortion weight (&lt;i&gt;p&lt;\/i&gt; = 0.03 and &lt;i&gt;p&lt;\/i&gt; = 0.009, respectively) than in those without intra-amniotic inflammation. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Both phenotypes of intra-amniotic inflammation, with sterile intra-amniotic inflammation being more frequent, are associated with worse outcomes in pregnancies with cervical insufficiency with prolapsed fetal membranes.<\/jats:p>","DOI":"10.1159\/000512102","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T17:03:32Z","timestamp":1607447012000},"page":"58-69","source":"Crossref","is-referenced-by-count":49,"title":["Intra-Amniotic Infection and Sterile Intra-Amniotic Inflammation in Cervical Insufficiency with Prolapsed Fetal Membranes: Clinical Implications"],"prefix":"10.1159","volume":"48","author":[{"given":"Martina","family":"Chalupska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Kacerovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslav","family":"Stranik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Gregor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Maly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Jacobsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Musilova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,12,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.12.002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000443276.68274.cc"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000185"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3109\/00016349409013390"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168285"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000187896.04535.e6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000197"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2018.08.010"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9378(12)80043-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/s0029-7844(99)00633-x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.04.019"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.960836"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.11.047"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)32967-X"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1095182"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.667177"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9378(16)32698-9"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e328332a8ba"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.03.017"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12296"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.958463"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.954243"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3837"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.03.069"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119355"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1006620"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1006621"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0913"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.2196\/16204"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(78)80282-0"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133929"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1991.tb15395.x"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2010.040"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12928"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13030"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1103729"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.03.018"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.01.043"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2009.03.020"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.03155.x"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2011.23.2.77"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-012-0527-z"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2016.57.5.1271"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2012-0038"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.171"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.1.44-47.2001"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200402000-00019"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.01.050"},{"key":"ref49","doi-asserted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