{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:52:14Z","timestamp":1787017934587,"version":"build-2736575974"},"reference-count":27,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Clinical outcome in patients with acute ischemic stroke (AIS) caused by large vessel occlusion (LVO) is not satisfactory if reperfusion treatment fails or is not tried. &lt;b&gt;&lt;i&gt;Aims:&lt;\/i&gt;&lt;\/b&gt; We aimed to assess the efficacy and safety of urgent superficial temporal-to-middle cerebral artery (STA-MCA) bypass surgery in selected patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Patients who were diagnosed with LVO-induced AIS in the anterior circulation but had a failed intra-arterial thrombectomy (IAT) or were not tried due to IAT contraindications were prospectively enrolled. Timely urgent STA-MCA bypass surgery was performed if they showed perfusion-diffusion mismatch or symptom-diffusion mismatch in the acute phase of disease. Clinical and radiological data of these patients were assessed to demonstrate the safety and efficacy of urgent bypass procedures. A pooled analysis of published data on urgent bypass surgery in acute stroke patients was conducted and analyzed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In 18 patients who underwent timely bypass, the National Institutes of Health Stroke Scale (NIHSS) score improved from 12.11 \u00b1 4.84 to 9.89 \u00b1 6.52, 1 week after surgery. Three-month and long-term (9.72 \u00b1 5.00 months) favorable outcomes (modified Rankin Scale [mRS] scores 0\u20132) were achieved in 50 and 75% of the patients, respectively. The pooled analysis (117 patients from 10 articles, including ours) identified favorable mRS scores in 71.79% patients at 3 months. A significant NIHSS score improvement from 11.51 \u00b1 4.89 to 7.59 \u00b1 5.50 was observed after surgery with significance. Major complications occurred in 3 patients (2.6%, 3\/117) without mortality. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Urgent STA-MCA bypass surgery can be regarded as a safe optional treatment to prevent cerebral infarct expansion and to improve clinical and radiological outcomes in highly selected patients.<\/jats:p>","DOI":"10.1159\/000512106","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T17:12:45Z","timestamp":1610125965000},"page":"34-45","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy and Safety of Timely Urgent Superficial Temporal Artery-to-Middle Cerebral Artery Bypass Surgery in Patients with Acute Ischemic Stroke: A Single-Institutional Prospective Study and a Pooled Analysis"],"prefix":"10.1159","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8557-1627","authenticated-orcid":false,"given":"Jang Hun","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3715-0718","authenticated-orcid":false,"given":"Wonki","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Kyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9852-4803","authenticated-orcid":false,"given":"Haewon","family":"Roh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0061-1640","authenticated-orcid":false,"given":"Hee Jin","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taek-Hyun","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-il","family":"Suh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungmi","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyuha","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713973"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706442"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61299-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411587"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414905"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415061"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2014.12.002"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198511073131904"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1610"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3171\/2009.5.JNS081556"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e318207a9de"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-013-0487-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2012.11.022"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2015.07.053"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.5137\/1019-5149.JTN.8648-13.1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.10.009"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.04.057"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/ons\/opx041"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.10.005"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-018-3576-y"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000082721.62796.09"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2009.00337.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.008547"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5912"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12436"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015151586"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyy411"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:14:05Z","timestamp":1745410445000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,2,9]]},"published-print":{"date-parts":[[2021,2,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000512106","archive":["Portico"],"relation":{},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"value":"1015-9770","type":"print"},{"value":"1421-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}