{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T04:26:43Z","timestamp":1776486403780,"version":"3.51.2"},"reference-count":43,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; The thyroid parafollicular hormone calcitonin (CT) shows particularly high blood levels in early childhood, a period of high bone turnover, which decrease with increasing age. Data about the physiological role of CT during infancy, childhood, and adolescence are contradictory or lacking. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; We hypothesize that CT demonstrates age-related correlations with parameters of bone growth and turnover as well as with parameters of calcium homeostasis. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; 5,410 measurements of anthropometric data and venous blood samples were collected from 2,636 participants of the LIFE Child study, aged 2 months\u201318 years. Univariate correlations and multiple regression analysis were performed between serum CT and anthropometric indicators (height standard deviation scores [SDS] and BMI-SDS), markers of calcium (Ca) homeostasis (Ca, parathyroid hormone, 25-OH vitamin D, and phosphate [P]), bone formation (procollagen type 1 N-terminal propeptide [P1NP], osteocalcin), and bone resorption (\u03b2-CrossLaps). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; CT was significantly associated with Ca (\u03b2 = 0.26, &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05) and P1NP\/100 (\u03b2 = 0.005, &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05) in children aged 2 months\u20131.1 years. These relations were independent of age and sex and could not be confirmed in children aged 1.1\u20138 years. Independent of age, sex, puberty, P, and height SDS CT showed a significant positive relation to Ca (\u03b2 = 0.26; &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001) in children aged 8\u201318 years. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Our findings suggest a unique association between CT and Ca in periods of rapid bone growth and point to a possible involvement of CT in promoting bone formation during the first year of life. <\/jats:p>","DOI":"10.1159\/000512107","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T22:01:09Z","timestamp":1607724069000},"page":"361-370","source":"Crossref","is-referenced-by-count":6,"title":["Age-Related Association of Calcitonin with Parameters of Anthropometry, Bone and Calcium Metabolism during 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