{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:53:43Z","timestamp":1787313223431,"version":"build-2736575974"},"reference-count":22,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Pharmacol Physiol"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> Psoriasis known as a chronic inflammatory skin disease is accompanied by metabolic disorders such as obesity, diabetes, and dyslipidemia. Vaspin (a serine protease inhibitor derived from visceral adipose tissue) is a newly identified adipokine and a link between inflammation and obesity has been reported. We aimed to determine whether vaspin gene polymorphism is associated with the development and\/or clinical features of psoriasis vulgaris. <b><i>Methods:<\/i><\/b> Our study group consisted of 96 psoriasis vulgaris patients and 100 matched controls. Vaspin rs2236242 gene was genotyped using PCR. <b><i>Results:<\/i><\/b> The vaspin genotypes showed a meaningful difference between psoriasis and control groups (<i>p<\/i> = 0.02). The frequency of the vaspin rs2236242 TT genotype was lower in psoriasis patients than in control participants (<i>p<\/i> &#x3c; 0.05). The TA genotype was associated with a 2.38-fold increased risk of psoriasis compared to the TT genotype (<i>p<\/i> = 0.007, odds ratio: 2.38; 95% confidence interval: 1.25\u20134.55), but not the AA genotype. All subjects were the Turkish population, the study in other populations is needed and the sample size was small in number. <b><i>Conclusion:<\/i><\/b> Our study demonstrated that vaspin rs2236242 polymorphism is related to psoriasis in the Turkish population. Polymorphisms of the vaspin gene might serve as diagnostic biomarkers of psoriasis.<\/jats:p>","DOI":"10.1159\/000512124","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T17:00:37Z","timestamp":1608310837000},"page":"317-322","source":"Crossref","is-referenced-by-count":8,"title":["Association between Vaspin rs2236242 Gene Polymorphism and Psoriasis Vulgaris"],"prefix":"10.1159","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9116-5489","authenticated-orcid":false,"given":"Nazli","family":"Dizen-Namdar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raziye","family":"Akcilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Bayat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3140682"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.040"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2019.1583207"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.10.030"},{"key":"ref5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01460.x"},{"key":"ref7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1081499"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3109\/07435800.2015.1066802"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.08.048"},{"key":"ref11"},{"key":"ref12"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2016.28.1.74"},{"key":"ref14"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01210.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2007-8-6-r107"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301737"},{"key":"ref18"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002737"},{"key":"ref20"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(85)70188-0"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2018.1459698"}],"container-title":["Skin Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512124","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:14:12Z","timestamp":1745410452000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":22,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,2,26]]},"published-print":{"date-parts":[[2021,3,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000512124","archive":["Portico"],"relation":{},"ISSN":["1660-5527","1660-5535"],"issn-type":[{"value":"1660-5527","type":"print"},{"value":"1660-5535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}