{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:09:21Z","timestamp":1780092561828,"version":"3.54.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> Citicoline represents a dietary source of choline, an essential nutrient, and precursor of cell membrane components, highly required during development and post-injury recovery. <b><i>Objectives:<\/i><\/b> We previously showed that perinatal asphyxia (PA) induces hippocampal neuroinflammation and injury that are subject to epigenetic change by maternal diet. The present study investigates maternal citicoline-supplemented diet (CSD) impact on offspring hippocampal response to PA. <b><i>Methods:<\/i><\/b> Six-day-old Wistar rats from mothers with standard-diet or CSD were exposed to PA. The hippocampal inflammation and injury were assessed by interleukin-1 beta (IL-1b), tumor necrosis factor-alpha (TNF\u03b1), and S-100B protein (S-100B), 24\u201348 h post-asphyxia. The microRNAs species miR124, miR132, miR134, miR146, and miR15a were measured from the hippocampus 24 h post-asphyxia, to investigate its epigenetic response to PA and maternal diet. At maturity, the offspring\u2019s behavior was analyzed using open field (OFT), T-maze (TMT), and forced swimming (FST) tests. <b><i>Results:<\/i><\/b> Our data show that the maternal CSD decreased IL-1b (<i>p<\/i> = 0.02), TNF\u03b1 (<i>p<\/i> = 0.007), and S100B (<i>p<\/i> = 0.01) at 24 h postexposure, upregulated miR124 (<i>p<\/i> = 0.03), downregulated miR132 (<i>p<\/i> = 0.002) and miR134 (<i>p<\/i> = 0.001), shortened the immobility period in FST (<i>p<\/i> = 0.01), and increased the percentage of passed trials in TMT (<i>p<\/i> = 0.01) compared to standard-diet. <b><i>Conclusions:<\/i><\/b> Maternal CSD reduces hippocampal inflammation and S100B level, triggers epigenetic changes related to homeostatic synaptic plasticity, memory formation, and neuronal tolerance to asphyxia, decreases the depressive-like behavior, and improves the lucrative memory in offspring subjected to PA. Thus, citicoline could be valuable as a maternal dietary strategy in improving the brain response to PA. <\/jats:p>","DOI":"10.1159\/000512145","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T22:14:53Z","timestamp":1612908893000},"page":"729-735","source":"Crossref","is-referenced-by-count":10,"title":["Maternal Citicoline-Supplemented Diet Improves the Response of the Immature Hippocampus to Perinatal Asphyxia in Rats"],"prefix":"10.1159","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2687-2611","authenticated-orcid":false,"given":"Sebastian","family":"Isac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca Maria","family":"Panaitescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9766-1558","authenticated-orcid":false,"given":"Mara Ioana","family":"Iesanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad","family":"Zeca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9961-8414","authenticated-orcid":false,"given":"Natalia","family":"Cucu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1997-7578","authenticated-orcid":false,"given":"Leon","family":"Zagrean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gheorghe","family":"Peltecu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4302-629X","authenticated-orcid":false,"given":"Ana-Maria","family":"Zagrean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,12,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11071569"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700692RR"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.26.061505.111156"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00068"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000454982"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2014.00008"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000491383"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.06.003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4183\/aeb.2018.315"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.08.031"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3791\/52587"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10403"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2174\/138945013804806424"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.05.029"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.253"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9545646"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1950"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12400"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(93)90113-p"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-014-0144-8"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:14:20Z","timestamp":1745424860000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":21,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,2,9]]},"published-print":{"date-parts":[[2021,2,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000512145","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}