{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T11:31:57Z","timestamp":1784374317178,"version":"3.55.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerontology"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> Lung ultrasound (LUS) showed a promising role in the diagnosis and monitoring of patients hospitalized for novel coronavirus disease (COVID-19). However, no data are available on its role in elderly patients. <b><i>Aims:<\/i><\/b> The aim of this study was to evaluate the diagnostic and prognostic role of LUS in elderly patients hospitalized for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pneumonia. <b><i>Methods:<\/i><\/b> Consecutive elderly patients (age &#x3e;65 years) hospitalized for COVID-19 were enrolled. Demographics, laboratory, comorbidity, and the clinical features of the patients were collected. All patients underwent LUS on admission to the ward. LUS characteristics have been analyzed. Uni- and multivariate analyses to evaluate predictors for in-hospital death were performed. <b><i>Results:<\/i><\/b> Thirty-seven hospitalized elderly patients (19 men) with a diagnosis of SARS-CoV-2 infection were consecutively enrolled. The median age was 82 years (interquartile range 74.5\u201393.5). Ultrasound alterations were found in all patients enrolled; inhomogeneous interstitial syndrome with spared areas (91.9%) and pleural alterations (100%) were the most frequent findings. At univariate analysis, LUS score (hazard ratio [HR] 1.168, 95% CI 1.049\u20131.301) and pleural effusions (HR 3.995, 95% CI 1.056\u201315.110) were associated with in-hospital death. At multivariate analysis, only LUS score (HR 1.168, 95% CI 1.049\u20131.301) was independelty associated with in-hospital death. The LUS score\u2019s best cutoff for distinguishing patients experiencing in-hospital death was 17 (at multivariate analysis LUS score \u226517, HR 4.827, 95% CI 1.452\u201316.040). In-hospital death was significantly different according to the LUS score cutoff of 17 (<i>p<\/i> = 0.0046). <b><i>Conclusion:<\/i><\/b> LUS could play a role in the diagnosis and prognosis in elderly patients hospitalized for SARS-CoV-2 infection. <\/jats:p>","DOI":"10.1159\/000512209","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T22:01:32Z","timestamp":1607032892000},"page":"78-86","source":"Crossref","is-referenced-by-count":19,"title":["Clinical Role of Lung Ultrasound for the Diagnosis and Prognosis of Coronavirus Disease Pneumonia in Elderly Patients: A Pivotal Study"],"prefix":"10.1159","volume":"67","author":[{"given":"Guerino","family":"Recinella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Marasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Tufoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Brizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Evangelisti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Maestri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Fusconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Calogero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Magalotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Zoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.5394"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-02895-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15412"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2017.04.017"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-05996-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202003_20549"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/10.1_part_1.20"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/9.3_part_1.179"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2513-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-015-0091-2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9051548"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30086-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s13089-020-00171-w"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15412"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.20-0323"}],"container-title":["Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:14:50Z","timestamp":1745424890000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,3]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,28]]},"published-print":{"date-parts":[[2021,2,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000512209","archive":["Portico"],"relation":{},"ISSN":["0304-324X","1423-0003"],"issn-type":[{"value":"0304-324X","type":"print"},{"value":"1423-0003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,3]]}}}