{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:53:37Z","timestamp":1777654417935,"version":"3.51.4"},"reference-count":42,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Thrombocytopenia has been identified as an independent risk factor for retinopathy of prematurity (ROP), although underlying mechanisms are unknown. In this study, the association of platelet count and serum platelet-derived factors with ROP was investigated. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Data for 78 infants born at gestational age (GA) &amp;#x3c;28 weeks were included. Infants were classified as having no\/mild ROP or severe ROP. Serum levels of vascular endothelial growth factor A, platelet-derived growth factor BB, and brain-derived neurotrophic factor were measured in serum samples collected from birth until postmenstrual age (PMA) 40 weeks. Platelet counts were obtained from samples taken for clinical indication. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Postnatal platelet counts and serum concentrations of the 3 growth factors followed the same postnatal pattern, with lower levels in infants developing severe ROP at PMA 32 and 36 weeks (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05\u20130.001). With adjustment for GA, low platelet counts and low serum concentrations of all 3 factors at PMA 32 weeks were significantly associated with severe ROP. Serum concentrations of all 3 factors also strongly correlated with platelet count (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; In this article, we show that ROP, platelet counts, and specific pro-angiogenic factors correlate. These data suggest that platelet-released factors might be involved in the regulation of retinal and systemic angiogenesis after extremely preterm birth. Further investigations are needed. <\/jats:p>","DOI":"10.1159\/000512282","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T17:39:34Z","timestamp":1616521174000},"page":"18-27","source":"Crossref","is-referenced-by-count":32,"title":["Decreased Platelet Counts and Serum Levels of VEGF-A, PDGF-BB, and BDNF in Extremely Preterm Infants Developing Severe ROP"],"prefix":"10.1159","volume":"118","author":[{"given":"Gunnel","family":"Hellgren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia","family":"Lundgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldina","family":"Pivodic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chatarina","family":"L\u00f6fqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders K.","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"S\u00e4vman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7644-6410","authenticated-orcid":false,"given":"Lois E.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9259-1244","authenticated-orcid":false,"given":"Ann","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,2,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2004.03.030"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2018.04.002"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2011.07.006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000448161"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31821e5f44"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-015-2972-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181cafc30"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/212183"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2017.11.009"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu113"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-113837"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2014.909022"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.04.012"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04773.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0027"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12250"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5323.242"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-013-9402-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(00)01302-8"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000317779"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181d01a36"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14841"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2015.09.007"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2012.1.512"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159\/000012095"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v6.i1.84"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1042\/cs0940395"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2017.04.004"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.991"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.12.1684"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.99448"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002028"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v46.4.567.567"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1038\/222033a0"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018024372"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.7727\/wimj.2014.210"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613072"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1006\/prep.1995.1062"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63214-2"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-308828"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.181"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-334524"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:15:50Z","timestamp":1745424950000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,3,24]]},"published-print":{"date-parts":[[2021,3,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000512282","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}