{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:17:59Z","timestamp":1792588679574,"version":"4.5.0"},"reference-count":14,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>A 64-year-old man with nephrotic syndrome was admitted to another hospital where his renal biopsy revealed membranoproliferative glomerulonephritis (MPGN) with monoclonal immunoglobulin (Ig) G, subclass 1, \u03ba light chain (IgG1\u03ba) deposition on immunofluorescence (IF). Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) was suspected due to monoclonal IgG1\u03ba deposits and the absence of hematological abnormalities. However, the typical PGNMID phenotype was not observed by electron microscopy. Instead, an organized and striated muscle-like structure was observed in the subendothelial space. Since a 2-year treatment with immunosuppressants did not improve his proteinuria, a second biopsy was performed at our hospital. It showed an MPGN-like phenotype; however, monoclonal Ig deposits on IF were no longer observed. One year after the second biopsy, he developed ESRD. Thus, he underwent living kidney transplantation from his wife. Allograft biopsy was performed as proteinuria was observed 3 months after transplantation, which again showed an MPGN-like phenotype with monoclonal IgG1\u03ba deposits. The observed electron-dense deposits were similar to those in the native biopsies. Accordingly, the patient was diagnosed with recurrent MPGN. Adding methylprednisolone pulse therapy to conventional immunosuppressants did not improve the patient\u2019s renal function or proteinuria. He died of Legionella pneumonia 8 months after transplantation. Considering the patient\u2019s histological findings of MPGN with monoclonal IgG1\u03ba deposits and early recurrence of glomerulonephritis after transplantation, he was diagnosed with PGNMID with novel electron-dense deposits. <\/jats:p>","DOI":"10.1159\/000512330","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T22:01:29Z","timestamp":1606168889000},"page":"43-48","source":"Crossref","is-referenced-by-count":7,"title":["Recurrence of Proliferative Glomerulonephritis with Monoclonal Immunoglobulin G Deposits with a Striated Ultrastructure"],"prefix":"10.1159","volume":"144","author":[{"given":"Tomoko","family":"Namba-Hamano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2100-9106","authenticated-orcid":false,"given":"Takayuki","family":"Hamano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoichi","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Kyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Yonishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeaki","family":"Nakazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taigo","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyofumi","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyaji","family":"Kyakuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitsugu","family":"Takabatake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Nonomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Isaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,11,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013036"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg102"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.08.030"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00365.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.408"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.01.028"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009010110"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s13730-013-0104-z"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1043\/1543-2165-134.4.512"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq037"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080\/01913123.2017.1336189"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.02.020"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.195"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s13730-018-0351-0"}],"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/nef\/article-pdf\/144\/Suppl.%201\/43\/4007872\/000512330.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/nef\/article-pdf\/144\/Suppl.%201\/43\/4007872\/000512330.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:16:24Z","timestamp":1745424984000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":14,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2021,1,18]]},"published-print":{"date-parts":[[2021,2,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000512330","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}