{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:09:31Z","timestamp":1788390571525,"version":"build-2803163510"},"reference-count":24,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The acid-labile subunit (ALS) is a crucial factor in the tertiary complex. IGF-I and IGFBP-3 are routinely measured during the diagnostic work-up for growth hormone deficiency (GHD). The aim of the study is to evaluate the relevance of serum ALS as an additional biomarker in the diagnosis of GHD. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Ninety-one children undergoing standard diagnostic work-up for GHD were included in this retrospective study. Inclusion criteria were evidence-based auxological cutoffs, IGF-I and IGFBP-3 &amp;#x3c;\u22122 SDS at first presentation, at least 1 growth hormone (GH) stimulation test, and IGF-I, IGFBP-3, and ALS measurements on the same day. Statistical analysis was performed by ROC as well as by odds ratio calculations. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Forty-seven of 90 participants presented with peak GH values under the cutoff of 7 ng\/mL. AUC from a model containing only IGF-I was 0.76 and 0.68 when using only ALS. A model containing IGF-I, IGFBP-3, and ALS (AUC = 0.77) did not improve the result compared to the combination of IGF-I\/IGFBP-3 (0.77) or IGF-I\/ALS (0.76). Furthermore, the variation in the outcome (GH peak &amp;#x3c;\/\u22657) explained by IGF-I only amounts to 20.4%, while that explained by IGFBP-3 and ALS is only 10.6 and 7.8%, respectively. The sensitivity to diagnose GHD at respective concentrations of \u22122.0 SDS was 48% for IGF-I, 38% for IGFBP-3, and only 8% for ALS. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Determination of serum ALS alone or in combination with IGF-I and IGFBP-3 did not improve definition of biochemical GHD in a cohort of short children and adolescents with suspected growth disorder. However, performance of IGFBP-3 in this context was not statistically superior to ALS. <\/jats:p>","DOI":"10.1159\/000512336","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T22:00:37Z","timestamp":1608328837000},"page":"371-379","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic Value of Serum Acid-Labile Subunit Alone and in combination with IGF-I and IGFBP-3 in the Diagnosis of Growth Hormone Deficiency"],"prefix":"10.1159","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9404-0975","authenticated-orcid":false,"given":"Diana-Alexandra","family":"Ertl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Gleiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Janu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Sagmeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3551-594X","authenticated-orcid":false,"given":"Adalbert","family":"Raimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Riedl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-3447","authenticated-orcid":false,"given":"Gabriele","family":"Haeusler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.22.1.0419"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000184186"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000452150"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-307228"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0105"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2011.05.007"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030412"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb01891.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1440245"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000355017"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.83.12.5311"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.49.379"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.120188"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3109\/03014460.2013.776110"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3060"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3059"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-014-0299-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0165"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1486"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.20945\/2359-3997000000192"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-06-0592"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.82.2.3750"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-014-2406-3"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2009.09.004"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512336","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:16:26Z","timestamp":1745424986000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,2,5]]},"published-print":{"date-parts":[[2021,2,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000512336","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}