{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:13:48Z","timestamp":1792214028176,"version":"4.4.0"},"reference-count":7,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>Chylothorax is a rare but life-threatening condition in newborns, often requiring a prolonged hospital stay. To date, no unified guidance exists for best management approach. Octreotide, a somatostatin analogue, has been used to treat neonatal chylothorax due to its effect on the splanchnic circulation and lipid absorption. It is administered either subcutaneously or intravenously; for the latter, a dose range between 1 and 10 \u00b5g\/kg\/h is most commonly used. However, the optimal dose and way of administration remain unclear. Here, we report 2 newborn cases with large volume chylothorax (&amp;#x3e;500 mL\/day), one with congenital chylothorax and one following a repair of a congenital diaphragmatic hernia (post-operative form). In both cases, a significant and sustained reduction in the volume of evacuated chyle was only seen once the dose of intravenous octreotide was increased to 20 \u00b5g\/kg\/h. We suggest that high-dose octreotide can be considered in seemingly refractory cases of neonatal chylothorax. <\/jats:p>","DOI":"10.1159\/000512461","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T22:01:15Z","timestamp":1611612075000},"page":"122-126","source":"Crossref","is-referenced-by-count":10,"title":["Should Newborns with Refractory Chylothorax Be Tried on Higher Dose of Octreotide?"],"prefix":"10.1159","volume":"118","author":[{"given":"Geza","family":"Vass","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ria","family":"Evans Fry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7965-4637","authenticated-orcid":false,"given":"Charles C.","family":"Roehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,1,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2017.03.010"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-006-0114-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000235256.00265.C8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000330413"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2015.04.008"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2005.20.6.947"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2015.10"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512461","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:17:08Z","timestamp":1745425028000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,3,24]]},"published-print":{"date-parts":[[2021,3,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000512461","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}