{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:26:24Z","timestamp":1751383584300,"version":"3.40.5"},"reference-count":21,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to investigate the performance of screening for open spina bifida (OSB) integrated into the routine first-trimester screening. &lt;b&gt;&lt;i&gt;Method:&lt;\/i&gt;&lt;\/b&gt; This is a prospective multicentre study of 4,755 women undergoing first-trimester ultrasound scans over a 4-year period. Measurements of the brainstem (BS) diameter and brainstem-to-occipital-bone (BSOB) distance were performed. The cisterna magna (CM) was measured in the tilted axial view. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Pregnancy outcome data were available for 4,658 fetuses included in this study. There were 5 fetuses with OSB, and in all of them, the BS\/BSOB ratio and the CM measurements were abnormal. The sensitivity and specificity of a BS\/BSOB ratio &amp;#x3e;1 were 100%. The sensitivity of a CM width &amp;#x3c;5th centile was 100%, and the specificity was 95.1%. In 4.6% of cases, the BS\/BSOB ratio was between the 95th percentile and 1. In 87.1% of these cases, the CM was normal, and 12.9% had a CM below the 5th percentile. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Screening for OSB is feasible in routine first-trimester scans. The BS\/BSOB ratio shows a very good sensitivity and specificity. In cases with near-normal values for the BS\/BSOB ratio, the CM width might be helpful for further assessment. <\/jats:p>","DOI":"10.1159\/000512487","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T22:01:36Z","timestamp":1612389696000},"page":"96-102","source":"Crossref","is-referenced-by-count":4,"title":["Screening for Open Spina Bifida in a Routine Clinical Setting at the First-Trimester Scan: A Prospective Multicentre Cohort Study"],"prefix":"10.1159","volume":"48","author":[{"given":"Johanna","family":"Tiechl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7009-8352","authenticated-orcid":false,"given":"Samira","family":"Abdel Azim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Leitner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Mutz-Dehbalaie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Goebel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9389-4258","authenticated-orcid":false,"given":"Matthias","family":"Scheier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,2,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h5949"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(86)91610-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20844"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7329"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10128"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8957"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2632"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9067"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.02.052"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0192-19.2019"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10111"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2011.30.12.1643"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12463"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000365989"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000365920"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1399483"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5614"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4883"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/cga.12223"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12302"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3973"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512487","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:17:31Z","timestamp":1745425051000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,26]]},"published-print":{"date-parts":[[2021,3,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000512487","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2021]]}}}