{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:59:01Z","timestamp":1775746741427,"version":"3.50.1"},"reference-count":11,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> <i>Helicobacter pylori<\/i> (<i>H. pylori<\/i>) is the most common chronic bacterial infection in the world, affecting over 50% of the world\u2019s population. <i>H. pylori<\/i> is a grade I carcinogen, responsible for the development of 89% of noncardia gastric cancers. In the present study, we analyzed the data for <i>H. pylori<\/i> eradication treatments in Slovenia after the 3rd national recommendations were implemented. <b><i>Patients and Methods:<\/i><\/b> Slovenia is part of the European Registry on <i>H. pylori<\/i> Management since the Registry was launched in 2013. Data were collected at Asociaci\u00f3n Espa\u00f1ola de Gastroenterolog\u00eda-Research Electronic Data Capture electronic case report form from September 2017 to December 2019. <i>H. pylori<\/i> eradication treatment was assessed by modified intention-to-treat (mITT) and per-protocol analyses. <b><i>Results:<\/i><\/b> Overall, 853 patients from 3 medical institutions were included. Effectiveness with first-line 14-day triple therapy with a proton-pomp-inhibitor (PPI), clarithromycin 500 mg, amoxicillin 1,000 mg, all BID, was 93% by mITT (714 patients). In patients allergic to penicillin, first-line 14-day triple therapy with PPI-clarithromycin-metronidazole achieved 83% effectiveness by mITT (35 patients). Second-line 14-day triple therapy with a PPI-amoxicillin-levofloxacin achieved 89% mITT eradication rate (51 patients). Second-line therapy with the 10-day three-in-one single capsule containing bismuth-tetracycline-metronidazole achieved optimal effectiveness (100% mITT) in 10 patients (<i>p<\/i> = 0.02). <b><i>Conclusions:<\/i><\/b> Slovenia is a country with &#x3c;15% <i>H. pylori<\/i> resistance to clarithromycin. Triple therapy with a PPI plus 2 antibiotics during 14 days reported optimal effectiveness (over 90%). Ten-day quadruple-bismuth second-line therapy had better results than 14-day triple therapy with levofloxacin. <\/jats:p>","DOI":"10.1159\/000512506","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T21:00:31Z","timestamp":1603486831000},"page":"318-324","source":"Crossref","is-referenced-by-count":7,"title":["<b><i>Helicobacter pylori<\/i><\/b> Eradication Rates in Slovenia in the Period from 2017 to 2019: Data from the European Registry on <b><i>H. pylori<\/i><\/b> Management"],"prefix":"10.1159","volume":"39","author":[{"given":"Bojan","family":"Tepes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasa","family":"Brglez Jurecic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Tepes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Espada Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Perez Nyssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colm","family":"O\u2019Morain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"M\u00e9graud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Gisbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302084"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309252"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2016.1178065"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000350719"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04887.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000350719"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3283643491"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302254"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i40.5669"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13128"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12686"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:17:38Z","timestamp":1745425058000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,23]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,6,30]]},"published-print":{"date-parts":[[2021,7,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000512506","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"value":"0257-2753","type":"print"},{"value":"1421-9875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,23]]}}}