{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:27:08Z","timestamp":1782289628333,"version":"3.54.5"},"reference-count":31,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; We aimed to characterize acute kidney injury (AKI), fluid overload (FO), and renal replacement therapy (RRT) utilization by diagnostic categories and examine associations between these complications and mortality by category. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; To test our hypotheses, we conducted a retrospective multicenter, cohort study including 446 neonates (categories: 209 with cardiac disease, 114 with congenital diaphragmatic hernia [CDH], 123 with respiratory disease) requiring extracorporeal membrane oxygenation (ECMO) between January 1, 2007, and December 31, 2011. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; AKI, FO, and RRT each varied by diagnostic category. AKI and RRT receipt were most common in those neonates with cardiac disease. Subjects with CDH had highest peak %FO (51% vs. 28% cardiac vs. 32% respiratory; &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.01). Hospital survival was 55% and varied by diagnostic category (45% cardiac vs. 48% CDH vs. 79% respiratory; &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001). A significant interaction suggested risk of mortality differed by diagnostic category in the presence or absence of AKI. In its absence, diagnosis of CDH (vs. respiratory disease) (OR 3.04, 95% CL 1.14\u20138.11) independently predicted mortality. In all categories, peak %FO (OR 1.20, 95% CL 1.11\u20131.30) and RRT receipt (OR 2.12, 95% CL 1.20\u20133.73) were independently associated with mortality. &lt;b&gt;&lt;i&gt;Discussion\/Conclusions:&lt;\/i&gt;&lt;\/b&gt; Physiologically distinct ECMO diagnoses warrant individualized treatment strategies given variable incidence and effects of AKI, FO, and RRT by category on mortality. <\/jats:p>","DOI":"10.1159\/000512538","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T22:00:38Z","timestamp":1611007238000},"page":"808-817","source":"Crossref","is-referenced-by-count":23,"title":["Acute Kidney Injury, Fluid Overload, and Renal Replacement Therapy Differ by Underlying Diagnosis in Neonatal Extracorporeal Support and Impact Mortality Disparately"],"prefix":"10.1159","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2168-4926","authenticated-orcid":false,"given":"Heidi J.","family":"Murphy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Gien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Sahay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Selewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Bridges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey M.","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Paden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Zappitelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja M.","family":"Gist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajit K.","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer G.","family":"Jetton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Askenazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000603"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000970"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181d8e348"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001349"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.02.010"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.03.031"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-014-3025-y"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.11.031"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e31816c6ed1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e31819ca3d0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/cc12830"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002231"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2017.201"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8090-5-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000173"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2009.119"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140674"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/00002480-200201000-00007"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.1997.tb03752.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s10047-005-0295-y"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.159"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3468(88)80331-2"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318228234b"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/cc9004"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3182772f61"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001806"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e3182579218"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611391"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32834f62d5"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512538","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:17:45Z","timestamp":1745425065000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,9,22]]},"published-print":{"date-parts":[[2021,9,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000512538","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.13603445","asserted-by":"subject"}]},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}