{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:27:07Z","timestamp":1745468827770,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>Eleven years ago, a 64-year-old Caucasian man had LNH Follicular 3a, IV A stage, FLIPI 2 as a prognostic index of follicular lymphoma. He received 8 cycles of RCHOP followed by rituximab maintenance, with complete remission. Due to a systemic recurrence, a new treatment schedule (RCOMP, 6 cycles) was introduced with partial remission persisting during a long-term maintenance treatment with rituximab. Three years ago, LNH Follicular 3a progressed into GC type diffuse large B-cell lymphomas (DLBCL); 6 cycles of rituximab and bendamustine were followed by R-ICE and R OXALI DHAP treatments without beneficial effect. Due to the worse general condition (ECOG 3\u20134), the patient was treated with pixantrone (6 cycles) until July 10, 2019, with a partial response. On Jan 13, 2020, an extreme compassioned treatment with venetoclax alone was started; this drug was well tolerated and provided a satisfactory clinical and laboratory improvement. In June 2020, however, he developed bone marrow toxicity and septic fever. Nasal and pharyngeal secretions were SARS-CoV-2 RNA negative. Blood cultures for mycotic agents and Gram-positive, Gram-negative, and anaerobic bacteria were negative, but few days later, the patients died of sepsis due to unidentified agents. The use of venetoclax as a single drug to treat DLBCL BCL2 patients deserves further investigation. <\/jats:p>","DOI":"10.1159\/000512541","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T22:00:41Z","timestamp":1611266441000},"page":"161-165","source":"Crossref","is-referenced-by-count":3,"title":["Rescue Therapy of Refractory Diffuse Large B-Cell Lymphomas BCL2 with Venetoclax: Case Report"],"prefix":"10.1159","volume":"65","author":[{"given":"Antonello","family":"Sica","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Sagnelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Vitiello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Franco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Argenziano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Ciccozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelista","family":"Sagnelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ronchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-3004"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1515\/med-2020-0018"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13795"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17030839"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-880526"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1515\/med-2019-0087"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2019-000551"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1515\/med-2020-0005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-01013-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018-0331"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-012-0305-y"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24436"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2011.07.016"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2020.1755859"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.23736\/S0026-4806.19.06395-X"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14490"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1515\/med-2019-0088"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2019.09.612"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0442-8"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.204958"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.14740\/jh473"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26197"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17030997"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3182a58ae0"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:17:46Z","timestamp":1745425066000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":24,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2021,2,26]]},"published-print":{"date-parts":[[2021,3,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000512541","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"type":"print","value":"0009-3157"},{"type":"electronic","value":"1421-9794"}],"subject":[],"published":{"date-parts":[[2020]]}}}